L-Methylfolate for Depression: The Real Deal?

You may have already seen journal advertisements for Deplin (www.deplin.com), a formulation of L-methylfolate produced by a company called Pamlab LLC. Touted as an “antidepressant food,” Pamlab claims it is “a first choice in depression augmentation.” Response rates to antidepressants are suboptimal, so any treatment that helps to improve symptoms without causing troublesome side effects would be a welcome addition. But can a nutritional supplement really relieve depression?

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