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Does Brintellix Bring Anything New?

After a dry spell of new antidepressants—the last one to be approved was levomilnacipran (Fetzima), the active enantiomer of milnacipran (Savella) in July 2013—the FDA approved vortioxetine (Brintellix) in September. Vortioxetine is another serotonergic antidepressant. How exactly does it work, and what are its advantages over existing drugs?

Future Developments in Antidepressant Therapy

In 2011 in the pages of TCPR, we asked, “What’s new in antidepressant treatment?” The answer was “not much” (TCPR, April 2011). In 2012, unfortunately, the answer isn’t very different.

Is It Possible that Antidepressants Really Don’t Work?

Antidepressant Roundup - The Carlat Psychiatry Report

A heated debate over how well psychiatric medications actually work has led some authorities in our field to suggest that psychiatry is currently experiencing a “crisis of confidence.”

Research Update

Non-Physical Adverse Effects of ADs May Be Underreported

All antidepressants have the potential to cause physical adverse effects, such as dry mouth, drowsiness, and dizziness. But patients often report psychological and interpersonal effects, too, and the fear of these adverse reactions sometimes leads patients to refuse these drugs. How common are non-physical side effects, such as apathy and feelings of detachment?

Do NSAIDs Keep Antidepressants From Working?

Do you know what other medications your depressed patients are taking? You should. If they’re taking non-steroidal anti-inflammatory drugs (NSAIDs), they may be less likely to respond to SSRIs.

Expert QA

Working With Primary Care Physicians in Treating Depression

In terms of starting new patients on antidepressants, PCPs do most of the prescribing.

The Motherisk Program

The Motherisk Program is a teratogen information service that has been around for more than 20 years.

Free Article

Four “New” Antidepressants. Or Are They? [Free Article]

What’s new in antidepressant treatment? Not much.