Depressive Disorder

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Which TMS Device Should You Buy?

So let’s say you’ve decided to take the TMS plunge. With three devices currently FDA cleared, you have some decisions to make. The following table brings together some information you might find useful focusing on the Neronetics and Brainsway devices.

Fisher Wallace and Alpha-Stim for Depression? Claims vs Evidence

Carly Simon swears by it. The daytime show “The Doctors” gave it a glowing review. Ads for it seem to be invading psychiatrists’ Google search results. We’re talking, of course, about the Fisher Wallace Stimulator and the similarly touted Alpha-Stim device. How do these devices work? Are they actually effective? And where do they fit into the rapidly expanding array of neuromodulators? 

Neurostimulation Devices for Depression: An Overview

When we last reviewed neurostimulation devices 3 years ago, we concluded that there was some promise—but more sizzle than beef. Now there are more devices and more data. But is there more beef? Maybe.

Research Update

Should We Add Stimulants to SSRIs to Treat Geriatric Depression?

Geriatric depression often presents with apathy, low energy and motivation, and cognitive decline, so theoretically stimulants are a natural choice. Past studies of combining stimulants with antidepressants have been mainly small open trials, with mostly positive results. But we haven’t seen the kind of rigorous double-blind methodology we’d like. A new study fills that gap. 

NSAIDs May be Effective for Depression

Inflammation is hot, both literally and figuratively. The medical literature is replete with studies implicating inflammation as a possible root cause of diseases as varied as heart disease, cancer, Alzheimer’s disease, depression and, of course, arthritis. A recent meta-analysis of all randomized controlled studies for depression yielded some intriguing results.

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Fisher Wallace and Alpha-Stim for Depression? Claims vs Evidence [Free Article]

Carly Simon swears by it. The daytime show “The Doctors” gave it a glowing review. Ads for it seem to be invading psychiatrists’ Google search results. We’re talking, of course, about the Fisher Wallace Stimulator and the similarly touted Alpha-Stim device. How do these devices work? Are they actually effective? And where do they fit into the rapidly expanding array of neuromodulators? 

Clinical Trials: Show Us the Data [Free Article]

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Depression
Depression - The Carlat Psychiatry Report (TCPR)

Too often our literature presents an oversimplified picture driven by some agenda, usually commercial. We prescribers, or, more accurately, “research consumers,” need a more complete and accurate description of what’s actually observed in clinical trials.

Deplin: Is it Just Folate by Another Name? [Free Article]

Deplin: Is it Just Folate by Another Name? - The Carlat Psychiatry Report

Patients are probably asking you about Deplin, or L-methylfolate, a version of folic acid that is being marketed by Pamlab as an adjunctive treatment for depression.