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Gabitril Fact Sheet

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Medication Name (brand): 
Medication Name (clinical): 


  • Adjunctive treatment of epilepsy.

  • A small amount of evidence for efficacy in anxiety; used sometimes for substance abusers as a non-addictive alternative to benzos, but evidence of efficacy for this is lacking.


GABA Reuptake Inhibitor

  • Supplied in 2 mg, 4 mg, 12 mg, and 16 mg tablets.

  • Dosing recommendations in PDR are applicable to epileptic patients already on other anti-seizure meds that induce Gabitril’s metabolism, so these are not applicable to typical psychiatric dosing.
  • In psychiatry, anecdotal reports suggest starting at 2 mg BID and increasing by 2 mg increments as needed. Max recommended PDR dose is 32 mg QD.
  • No dose adjustment required for elderly or in renal impairment. Reduce dose in patients with hepatic impairment.

Side Effects: 
  • Most common are dizziness, sedation, jitteriness, tremor, and impaired memory/concentration.

  • Postmarketing reports have shown that Gabitril can induce seizures in patients with no history of epilepsy, although this is rare.

Drug-drug Interactions: 

Metabolized by CYP 3A and several other enzymes. Enzyme inducers such as Tegretol (carbamazepine) may decrease Gabitril levels.

  • High fat meals decrease rate of absorption.

  • Half-life 7-9 hours.

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