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Home » Methadone vs Buprenorphine-Naloxone: Real-World Comparisons
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Research Update

Methadone vs Buprenorphine-Naloxone: Real-World Comparisons

April 1, 2026
Maryam Soltani, MD, PhD.
From The Carlat Addiction Treatment Report
Issue Links: Editorial Information | PDF of Issue

Maryam Soltani, MD. Dr. Soltani has no financial relationships with companies related to this material.

Two large cohort studies compared retention and ongoing opioid use among patients receiving methadone versus buprenorphine. Methadone showed slightly higher retention, while both medications reduced illicit opioid use effectively. Choosing between them remains a patient centered clinical decision.

Addiction Treatment
www.thecarlatreport.com
Issue Date: April 1, 2026
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Table Of Contents
Learning Objectives, Drug Trends CATR, April/May/June 2026
What Psychiatrists Should Know About Inhalants
Trends in Illicit Drug Use
Family Support in Substance Use Disorders
Prescription Drug Misuse and Diversion in Correctional Settings
Oral vs Injectable Naltrexone for Hospitalized Patients With AUD
Higher Buprenorphine Doses Lower Death Rates in the Fentanyl Era
Methadone vs Buprenorphine-Naloxone: Real-World Comparisons
Cannabis Use in OUD: Does Medication Type Make a Difference?
Early and Injectable-Only Buprenorphine Induction: Can You Skip Withdrawal?
CME Post-Test, Drug Trends, CATR, April/May/June 2026
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