Drug Metabolism (November/December)

Date of Issue: 11/01/2018 | Volume: 16 | Number: 11 & 12

Issue Links:Learning Objectives | Editorial Information

In this issue we dig through polypharmacy research to highlight a few useful combinations where the drug interaction can benefit your patient and features an Expert Q&A on the effects of drug interactions.

In This Issue


New Stimulants: From Remixed Amphetamines to Bedtime Ritalin

Topics: ADHD | Psychopharmacology Tips

You may have noticed that a confusing array of new stimulants has been approved in the last few years. Since 2012, there have been five new amphetamines and two new methylphenidates. What are these preparations? Are any of them worth prescribing to your patients?

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Harnessing Beneficial Drug Interactions

Topics: Practice Tools and Tips | Psychopharmacology Tips | Registered Articles

It’s nice when we can get our patients better with a single medication, but that’s not always possible. Sometimes the right combination of meds can do the trick, but studies of polypharmacy are scarce. In this article we dig through that research, small and limited as it is, to highlight a few useful combinations where the drug interaction can benefit your patient.

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Expert Q&A

Effects of Drug Interactions

Topics: Practice Tools and Tips | Psychopharmacology Tips

When it comes to computer alerts for drug interactions, the two issues to pay attention to are toxicity and loss of efficacy. Toxicity is the bigger concern, particularly if the drug has a “narrow therapeutic index,” where modest differences in the level can have dangerous effects.

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Ask the Editor: Which Antipsychotic Is Best When Patients Complain of Akathisia?

Topics: Antipsychotics

Akathisia is a sensation of inner restlessness so unpleasant that it independently elevates the risk of suicide. Among atypicals, quetiapine (Seroquel) has the lowest risk of akathisia, but that doesn’t mean it’s easy to take.

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Research Update

Probiotics for Bipolar Disorder

Topics: Bipolar Disorder | Research Update

Probiotics, the so-called “good” bacteria in the gut flora, have become popular as a natural treatment for various disorders. They are taken as capsules or through food sources like yogurt, vinegar, and fermented foods.

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Research Update

Does TMS Really Work in Depression?

Topics: Depressive Disorder | Free Articles | Research Update

Repetitive transcranial magnetic stimulation (rTMS) has been FDA-approved for treatment-resistant depression (TRD) since 2008. This non-invasive therapy uses an electromagnetic coil to stimulate electrical activity in the frontal cortex.

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Research Update

Is Clozapine the Next Step After a Single Failed Antipsychotic Trial?

Topics: Antipsychotics | Research Update

Clozapine is often used as a last resort in schizophrenia, even though practice guidelines recommend a trial of this medication after failing 2 antipsychotics. The current study set out to test a treatment algorithm based on those guidelines in patients with first-episode psychosis.

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News of Note

New Approvals for TMS

Topics: Brain Devices | News of Note

We know that transcranial magnetic stimulation (TMS) works for treatment-resistant depression (TRD), but one disadvantage is the length of the treatment sessions.

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CME Post-Test

CME Post-Test - Drug Metabolism, TCPR, November/December 2018

Topics: CME Post-Test

The post-test for this issue is available for one year after the publication date to subscribers only. By successfully completing the test you will be awarded a certificate for 2 CME credits.

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