Side Effects Part II (August)

Date of Issue: 08/01/2019 | Volume: 17 | Number: 8

Issue Links:Learning Objectives | Editorial Information

Practical tips on managing side effects. Folic acid and Deplin are compared side-by-side. A new treatment for bipolar depression is put in perspective, and questions are raised about an old standard for PTSD.

In This Issue


l-Methylfolate for Depression: Costly Mistake or Good Thinking?

Topics: Antidepressants | CAM Treatments | Deplin | Depression | Depressive Disorder | Folate | Folic Acid | l-methylfolate | methylfolate | Natural Medications | Nutrition | Pharmacology | Pharmacology Tips | Psychopharmacology | Psychopharmacology Tips | Treatment-Resistant Depression

Folic acid and l-methylfolate are two versions of the same vitamin. Both are popular for antidepressant augmentation, but one is a expensive prescription. We compared them side-by-side and found that one has a slight advantage.

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Expert Q&A

Medication Side Effects Part II: Weight Gain, Akathisia, Hair Loss, and Orthostasis

Topics: Akathisia | Falls | Hair loss | Orthostasis | Pharmacology Tips | Psychopharmacology Tips | Side Effects | Weight Loss Medications

Dr. Mago reveals his top strategies for common side effects. Featuring safe-dosing of metformin, vitamins for hair loss, and special stockings for orthostasis.

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News of Note

A New Treatment for Bipolar Depression

Topics: Antipsychotics | Atypical Antipsychotics | Bipolar Depression | Bipolar Disorder | Depression | News of Note | Pharmacology | Psychopharmacology

With Vrylar’s new approval, there are now four atypicals antipsychotics with an indication in bipolar depression. Only two of these, however, are known to work in mania as well as depression. None of the atypicals stands out as the perfect choice for bipolar depression, but there are pros and cons to each that make them fitter better with certain patients.

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Research Update

Another Black Eye for Prazosin in PTSD?

Topics: Hypnotics | Insomnia | Nightmares | Prazosin | PTSD | Research | Research Update | Sleep | Suicidality

Recent trials cast doubt on prazosin’s role in PTSD, but there are reasons to doubt their results.

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CME Post-Test

CME Post-Test - Side Effects Part II, TCPR, August 2019

Topics: CME Post-Test

The post-test for this issue is available for one year after the publication date to subscribers. By successfully completing the test you will be awarded a certificate for 1 CME credit.

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