Clear, engaging, and practical updates on clinical psychiatry.

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How to Stop Benzos and Stimulants

March 22, 2021 | Podcasts

Swapnil Gupta, author of Deprescribing in Psychiatry, shares tips on how to help patients taper off benzodiazepines and psychostimulants. She adds a special therapeutic ingredient, but it’s not a medication. Then we digress into one of the oldest medications known...


What Works Best in Treatment Resistant Depression Pt. 1

March 8, 2021 | Podcasts

What works best when the first antidepressant fails? And the second? Today, we bring you part 1 in our special series on treatment resistant depression. Published On: 3/7/21 Duration: 16 minutes, 1 second Published On: 3/7/21 Duration: 16 minutes, 1 second Transcript:...


How Buspirone Mixed with Melatonin to Make an Antidepressant

February 22, 2021 | Podcasts

In 2012, psychiatrists at Harvard’s Massachusetts General Hospital discovered a novel antidepressant. It seemed to improve depression and cognition without causing any significant side effects. There was only one problem. The ingredients were practically free, and there was no way...


When Depression Gets Worse on an Antidepressant

February 14, 2021 | Podcasts

Bupropion and restless legs syndrome: a randomized controlled trialWhen a patient complains that their mood got worse on an antidepressant, it doesn’t necessarily mean they are sensitive to medications. In this episode, we detail 6 other reasons why depression can...


Deprescribing Part 1

February 8, 2021 | Podcasts

An interview with Swapnil Gupta on when and how to come off psychiatric medications. Plus, tips on cross-tapering antidepressants, and the word of the day: Ephedra. Published On: 2/8/2021 Duration: 17 minutes, 1 second Transcript: Today, an interview with Swapnil Gupta on...


The Birth of Lamotrigine

January 25, 2021 | Podcasts

Richard Weisler tells the tale of science and serendipity that lead to his discovery of lamotrigine for bipolar depression 30 years ago. He shares a few dosing tips, and touches on how he works with patients and their families. Plus,...


Cognitive Enhancers: The Brain on Chess

January 11, 2021 | Podcasts

The Queen’s Gambit is Netflix’s critically acclaimed series about a chess prodigy who gets “a little help from her friends.” In this episode we find out what they got right, and wrong, about psychiatric meds and cognitive enhancement. Published On: 1/11/2020...