CARLAT PUBLISHING The Carlat Report https://www.thecarlatreport.com/rss/articles 14 Reasons Why Psychopharmacology Differs in Women, Part 4 Women clear some psychiatric medications more slowly, lose bone density at higher rates, and face greater medical consequences from alcohol and smoking than men. This final episode in a four-part series covers side effects, drug metabolism, drugs of abuse, urine incontinence, and what we do — and don't — know about prescribing for transgender patients. p.p1 {margin: 0.0px 0.0px 0.0px 0.0px; font: 12.0px Helvetica; color: #000000}

Women clear some psychiatric medications more slowly, lose bone density at higher rates, and face greater medical consequences from alcohol and smoking than men. This final episode in a four-part series covers side effects, drug metabolism, drugs of abuse, urine incontinence, and what we do — and don't — know about prescribing for transgender patients.

]]> Mon, 13 Jul 2026 02:00:00 -0400 https://www.thecarlatreport.com/blogs/2-the-carlat-psychiatry-podcast/post/6348-14-reasons-why-psychopharmacology-differs-in-women-part-4 http://www.thecarlatreport.com/blogs/2/post/6348 Catatonia and Delirium Can Coexist—and Lorazepam May Help Although DSM-5-TR cautions against diagnosing catatonia and delirium at the same time, real-world patients do not always fit neatly into one category. A prospective quality-improvement study of more than 700 medical inpatients found substantial overlap between the two syndromes, with implications for screening and treatment. Although DSM-5-TR cautions against diagnosing catatonia and delirium at the same time, real-world patients do not always fit neatly into one category. A prospective quality-improvement study of more than 700 medical inpatients found substantial overlap between the two syndromes, with implications for screening and treatment.

]]> Tue, 07 Jul 2026 06:15:02 -0400 https://www.thecarlatreport.com/articles/6347-catatonia-and-delirium-can-coexistand-lorazepam-may-help http://www.thecarlatreport.com/articles/6347 14 Reasons Why Psychopharmacology Differs in Women, Part 3 Estrogen shapes nearly every neurotransmitter system in the brain, and when it starts to fall, psychiatric disorders often follow. This episode walks through what psychiatrists need to know about the perimenopause: which conditions worsen, which treatments help, and when to call the OB-GYN about hormone replacement therapy. p.p1 {margin: 0.0px 0.0px 0.0px 0.0px; font: 12.0px Helvetica; color: #000000}

Estrogen shapes nearly every neurotransmitter system in the brain, and when it starts to fall, psychiatric disorders often follow. This episode walks through what psychiatrists need to know about the perimenopause: which conditions worsen, which treatments help, and when to call the OB-GYN about hormone replacement therapy.

]]> Mon, 06 Jul 2026 02:00:00 -0400 https://www.thecarlatreport.com/blogs/2-the-carlat-psychiatry-podcast/post/6344-14-reasons-why-psychopharmacology-differs-in-women-part-3 http://www.thecarlatreport.com/blogs/2/post/6344 CME Post-Test, Medical Contributors to Psychiatric Disorders, CGPR, July/August/September 2026 By successfully completing the test you will be awarded a certificate for 2 CME credits. By successfully completing the test you will be awarded a certificate for 2 CME credits.

]]> Wed, 01 Jul 2026 01:00:00 -0400 https://www.thecarlatreport.com/articles/6326-cme-post-test-medical-contributors-to-psychiatric-disorders-cgpr-july-august-september-2026 http://www.thecarlatreport.com/articles/6326 When Antidepressants Stop Working in Older Adults The evidence base for treatment-resistant depression was largely built on younger adults. This meta-analysis asks what works in patients 55 and older. One intervention stands out, especially when suicidality is in the picture. The evidence base for treatment-resistant depression was largely built on younger adults. This meta-analysis asks what works in patients 55 and older. One intervention stands out, especially when suicidality is in the picture.

]]> Wed, 01 Jul 2026 00:00:02 -0400 https://www.thecarlatreport.com/articles/6329-when-antidepressants-stop-working-in-older-adults http://www.thecarlatreport.com/articles/6329 Soft Drink Intake Linked to Depression: Gut Microbiome May Be the Missing Link Soft drinks are implicated in obesity and diabetes. But could they also influence depression—and if so, through what mechanism? A German cohort study of 932 adults points to an unexpected variable in the relationship between dietary habits and mood. Soft drinks are implicated in obesity and diabetes. But could they also influence depression—and if so, through what mechanism? A German cohort study of 932 adults points to an unexpected variable in the relationship between dietary habits and mood.

]]> Wed, 01 Jul 2026 00:00:00 -0400 https://www.thecarlatreport.com/articles/6346-soft-drink-intake-linked-to-depression-gut-microbiome-may-be-the-missing-link http://www.thecarlatreport.com/articles/6346 Learning Objectives, Medical Contributors to Psychiatric Disorders, CGPR, July/August/September 2026 After reading these articles, you should be able to… After reading these articles, you should be able to…

]]> Wed, 01 Jul 2026 00:00:00 -0400 https://www.thecarlatreport.com/articles/6335-learning-objectives-medical-contributors-to-psychiatric-disorders-cgpr-july-august-september-2026 http://www.thecarlatreport.com/articles/6335 Nootropics and Cognitive Health in Older Adults Older adults are increasingly turning to supplements and substances marketed for memory and cognition, and they’re asking their psychiatrists about them. Here’s what the evidence supports, and how to have that conversation without dismissing or overpromising. Older adults are increasingly turning to supplements and substances marketed for memory and cognition, and they’re asking their psychiatrists about them. Here’s what the evidence supports, and how to have that conversation without dismissing or overpromising.

]]> Wed, 01 Jul 2026 00:00:00 -0400 https://www.thecarlatreport.com/articles/6334-nootropics-and-cognitive-health-in-older-adults http://www.thecarlatreport.com/articles/6334 Recognizing and Managing Prion Disease Prion disease is uncommon but not rare, and psychiatrists are often the first clinicians to see it. Dr. Alice Uflacker explains how to recognize rapidly progressive cognitive and behavioral decline, when to refer, and how modern tools like MRI and RT-QuIC have transformed diagnosis. Palliative planning and family counseling are also addressed. Prion disease is uncommon but not rare, and psychiatrists are often the first clinicians to see it. Dr. Alice Uflacker explains how to recognize rapidly progressive cognitive and behavioral decline, when to refer, and how modern tools like MRI and RT-QuIC have transformed diagnosis. Palliative planning and family counseling are also addressed.

]]> Wed, 01 Jul 2026 00:00:00 -0400 https://www.thecarlatreport.com/articles/6333-recognizing-and-managing-prion-disease http://www.thecarlatreport.com/articles/6333 Food as Medicine in Older Adults Nutrition is already part of psychiatric pathophysiology, although it just rarely makes it into the visit. Dr. Rani Polak, a physician-chef and lifestyle medicine specialist, explains how psychiatrists can ask about diet, what nutritional deficiencies to screen for, and how cooking itself can restore structure, agency, and connection in older adults. Nutrition is already part of psychiatric pathophysiology, although it just rarely makes it into the visit. Dr. Rani Polak, a physician-chef and lifestyle medicine specialist, explains how psychiatrists can ask about diet, what nutritional deficiencies to screen for, and how cooking itself can restore structure, agency, and connection in older adults.

]]> Wed, 01 Jul 2026 00:00:00 -0400 https://www.thecarlatreport.com/articles/6332-food-as-medicine-in-older-adults http://www.thecarlatreport.com/articles/6332 Effectively Translating Knowledge into Practice Choosing the right treatment is only half the job. This article focuses on how to build care plans older adults can follow using teach-back, simplified written instructions, caregiver engagement, and trusted digital resources. Practical strategies address underuse of effective treatments, misuse from unclear plans, and overuse driven by complexity rather than clinical need. Choosing the right treatment is only half the job. This article focuses on how to build care plans older adults can follow using teach-back, simplified written instructions, caregiver engagement, and trusted digital resources. Practical strategies address underuse of effective treatments, misuse from unclear plans, and overuse driven by complexity rather than clinical need.

]]> Wed, 01 Jul 2026 00:00:00 -0400 https://www.thecarlatreport.com/articles/6331-effectively-translating-knowledge-into-practice http://www.thecarlatreport.com/articles/6331 Physical Activity and Mental Health: How Much Is Enough? How much exercise does it take to protect against depression and anxiety in older adults? A large accelerometer-based study puts a number on it, and finds the biggest gains happen at the very bottom of the activity spectrum. How much exercise does it take to protect against depression and anxiety in older adults? A large accelerometer-based study puts a number on it, and finds the biggest gains happen at the very bottom of the activity spectrum.

]]> Wed, 01 Jul 2026 00:00:00 -0400 https://www.thecarlatreport.com/articles/6330-physical-activity-and-mental-health-how-much-is-enough http://www.thecarlatreport.com/articles/6330 Vigorous Exercise Cuts Dementia Risk What if the key to protecting the aging brain isn’t how long patients exercise, but how hard? A comprehensive review suggests cardiorespiratory fitness — not step counts — is the variable that matters most for dementia prevention. What if the key to protecting the aging brain isn’t how long patients exercise, but how hard? A comprehensive review suggests cardiorespiratory fitness — not step counts — is the variable that matters most for dementia prevention.

]]> Wed, 01 Jul 2026 00:00:00 -0400 https://www.thecarlatreport.com/articles/6328-vigorous-exercise-cuts-dementia-risk http://www.thecarlatreport.com/articles/6328 A Simple Blood Test Matches a $5,000 Scan for Alzheimer’s Tau-PET is the gold standard for detecting preclinical Alzheimer’s pathology, but it costs thousands and isn’t widely available. What if a $200 blood test could do the same job? Tau-PET is the gold standard for detecting preclinical Alzheimer’s pathology, but it costs thousands and isn’t widely available. What if a $200 blood test could do the same job?

]]> Wed, 01 Jul 2026 00:00:00 -0400 https://www.thecarlatreport.com/articles/6327-a-simple-blood-test-matches-a-5-000-scan-for-alzheimers http://www.thecarlatreport.com/articles/6327 14 Reasons Why Psychopharmacology Differs in Women, Part 2 Premenstrual hormones can destabilize mood, worsen ADHD, trigger psychosis, and drive binge eating. This episode walks through the tools to manage hormonal fluctuations in female patients, from SSRIs to overlooked supplements to the lamotrigine-contraceptive drug interaction. p.p1 {margin: 0.0px 0.0px 0.0px 0.0px; font: 12.0px Helvetica; color: #000000}

Premenstrual hormones can destabilize mood, worsen ADHD, trigger psychosis, and drive binge eating. This episode walks through the tools to manage hormonal fluctuations in female patients, from SSRIs to overlooked supplements to the lamotrigine-contraceptive drug interaction.

]]> Mon, 29 Jun 2026 02:00:00 -0400 https://www.thecarlatreport.com/blogs/2-the-carlat-psychiatry-podcast/post/6340-14-reasons-why-psychopharmacology-differs-in-women-part-2 http://www.thecarlatreport.com/blogs/2/post/6340 Everything You Wanted To Know About Lithium But Hadn't Heard On The Podcast Yet Dr. Chris Aiken and Kellie Newsome, PMHNP have covered lithium quite a bit on The Carlat Psychiatry Podcast. Are you up to date on this cornerstone of psychiatry? Here's a clearinghouse of lithium episodes to catch you up. Dr. Chris Aiken and Kellie Newsome, PMHNP have covered lithium quite a bit on The Carlat Psychiatry Podcast. Are you up to date on this cornerstone of psychiatry? Here's a clearinghouse of lithium episodes to catch you up.        

]]> Mon, 22 Jun 2026 11:51:00 -0400 https://www.thecarlatreport.com/blogs/1-the-carlat-psychiatry-blog/post/6339-everything-you-wanted-to-know-about-lithium-but-hadnt-heard-on-the-podcast-yet http://www.thecarlatreport.com/blogs/1/post/6339 14 Reasons Why Psychopharmacology Differs in Women, Part 1 Women and men respond to psychiatric medications differently. In this first of a four-part series, Chris Aiken and Kellie Newsome walk through why valproate is risky for women, and when it’s worth using; why the FDA cut the zolpidem dose in half for female patients, and why SSRIs outperform tricyclics in women with depression. Plus: a sneak preview of DSM-6. p.p1 {margin: 0.0px 0.0px 0.0px 0.0px; font: 12.0px Helvetica; color: #000000}

Women and men respond to psychiatric medications differently. In this first of a four-part series, Chris Aiken and Kellie Newsome walk through why valproate is risky for women, and when it’s worth using; why the FDA cut the zolpidem dose in half for female patients, and why SSRIs outperform tricyclics in women with depression. Plus: a sneak preview of DSM-6.

]]> Mon, 22 Jun 2026 02:00:00 -0400 https://www.thecarlatreport.com/blogs/2-the-carlat-psychiatry-podcast/post/6338-14-reasons-why-psychopharmacology-differs-in-women-part-1 http://www.thecarlatreport.com/blogs/2/post/6338 Psilocybin: What You Need to Know Psilocybin is going mainstream: Trump has signed an executive order opening psychedelics to patients with severe mental illness, and one in eight American adults has already tried it. But as we dig into the research, a more complicated picture emerges, one that separates the profound personal experience from the clinical evidence. p.p1 {margin: 0.0px 0.0px 0.0px 0.0px; font: 12.0px Helvetica; color: #000000}

Psilocybin is going mainstream: Trump has signed an executive order opening psychedelics to patients with severe mental illness, and one in eight American adults has already tried it. But as we dig into the research, a more complicated picture emerges, one that separates the profound personal experience from the clinical evidence.
]]> Mon, 15 Jun 2026 02:00:00 -0400 https://www.thecarlatreport.com/blogs/2-the-carlat-psychiatry-podcast/post/6337-psilocybin-what-you-need-to-know http://www.thecarlatreport.com/blogs/2/post/6337 Rethinking 12-Step Referrals How to make a 12-step referral patients will actually try. How to make a 12-step referral patients will actually try. 

]]> Sat, 13 Jun 2026 16:00:00 -0400 https://www.thecarlatreport.com/blogs/1-the-carlat-psychiatry-blog/post/6336-rethinking-12-step-referrals http://www.thecarlatreport.com/blogs/1/post/6336 EMDR in Practice: A Clinician's Guide to Trauma Reprocessing with Roger Solomon, PhD Dr. Roger Solomon provides a comprehensive introduction to Eye Movement Desensitization and Reprocessing (EMDR). Dr. Roger Solomon provides a comprehensive introduction to Eye Movement Desensitization and Reprocessing (EMDR).

]]> Mon, 08 Jun 2026 02:00:00 -0400 https://www.thecarlatreport.com/blogs/2-the-carlat-psychiatry-podcast/post/6308-emdr-in-practice-a-clinicians-guide-to-trauma-reprocessing-with-roger-solomon-phd http://www.thecarlatreport.com/blogs/2/post/6308 The Latest in Child and Adolescent Psychiatry from Dr. Joshua Feder and Mara Goverman, LCSW. Five Free Episodes! Five free episodes on the issues that matter most in child and adolescent psychiatry today — from suicide risk in autistic youth to anxiety, sleep, legal systems, and expanding access to care. Hosted by Dr. Joshua Feder and Mara Goverman, LCSW. Five free episodes on the issues that matter most in child and adolescent psychiatry today — from suicide risk in autistic youth to anxiety, sleep, legal systems, and expanding access to care. Hosted by Dr. Joshua Feder and Mara Goverman, LCSW.

]]> Sat, 06 Jun 2026 20:55:09 -0400 https://www.thecarlatreport.com/blogs/1-the-carlat-psychiatry-blog/post/6323-the-latest-in-child-and-adolescent-psychiatry-from-dr-joshua-feder-and-mara-goverman-lcsw-five-free-episodes http://www.thecarlatreport.com/blogs/1/post/6323 3 Examples of AskCarlat AI Making a Difference in Clinical Work For 23 years, Dr. Carlat and his team of clinical experts have developed a mountain of peer-reviewed articles and books covering almost every aspect of psychiatry. Unlike many journals, these resources are straightforward, plain spoken, and actionable for the everyday work clinicians face. This year we took that massive archive and put it to work for you in a brand new interface called AskCarlat AI. For 23 years, Dr. Carlat and his team of clinical experts have developed a mountain of peer-reviewed articles and books covering almost every aspect of psychiatry. Unlike many journals, these resources are straightforward, plain spoken, and actionable for the everyday work clinicians face. This year we took that massive archive and put it to work for you in a brand new interface called AskCarlat AI.

]]> Sat, 06 Jun 2026 20:55:09 -0400 https://www.thecarlatreport.com/blogs/1-the-carlat-psychiatry-blog/post/6322-3-examples-of-askcarlat-ai-making-a-difference-in-clinical-work http://www.thecarlatreport.com/blogs/1/post/6322 Free Podcast Series: Gender Affirming Care in Exile Two malpractice cases — one worth $2 million — are reshaping the standards of gender-affirming care. This episode traces what went wrong, what held up in court, and what every clinician needs to know when referring patients for gender affirming procedures. Two malpractice cases — one worth $2 million — are reshaping the standards of gender-affirming care. This episode traces what went wrong, what held up in court, and what every clinician needs to know when referring patients for gender affirming procedures.



]]> Sat, 06 Jun 2026 00:00:00 -0400 https://www.thecarlatreport.com/blogs/1-the-carlat-psychiatry-blog/post/6324-free-podcast-series-gender-affirming-care-in-exile http://www.thecarlatreport.com/blogs/1/post/6324 Stimulant Medications for ADHD: Choosing the Right Approach for Adults Free Quick Reference Guide A treament overview of Methylphenidate and Amphetamine medicatoins for ADHD. A treament overview of Methylphenidate and Amphetamine medicatoins for ADHD.


]]> Sat, 06 Jun 2026 00:00:00 -0400 https://www.thecarlatreport.com/blogs/1-the-carlat-psychiatry-blog/post/6320-stimulant-medications-for-adhd-choosing-the-right-approach-for-adults-free-quick-reference-guide http://www.thecarlatreport.com/blogs/1/post/6320 Treatment of Bipolar Disorder in Pregnant and Postpartum Women: A Free Review Sheet Begin preparation at least six months before conception to ensure stability, switch to safer medications, and manage psychosocial stressors. Begin preparation at least six months before conception to ensure stability, switch to safer medications, and manage psychosocial stressors.

       


    ]]>     Sat, 06 Jun 2026 00:00:00 -0400 https://www.thecarlatreport.com/blogs/1-the-carlat-psychiatry-blog/post/6321-treatment-of-bipolar-disorder-in-pregnant-and-postpartum-women-a-free-review-sheet http://www.thecarlatreport.com/blogs/1/post/6321     Free Sample Resource - Most Common Clinically Significant Drug Interactions in Psychiatry Drug-drug interactions are critical to monitor in older adults due to the high prevalence of polypharmacy in this population. Drug-drug interactions are critical to monitor in older adults due to the high prevalence of polypharmacy in this population. 



    ]]>     Sat, 06 Jun 2026 00:00:00 -0400 https://www.thecarlatreport.com/blogs/1-the-carlat-psychiatry-blog/post/6319-free-sample-resource-most-common-clinically-significant-drug-interactions-in-psychiatry http://www.thecarlatreport.com/blogs/1/post/6319     Free Sample Section: Important Drug-Drug Interactions in Older Adults Drug-drug interactions are critical to monitor in older adults due to the high prevalence of polypharmacy in this population. Drug-drug interactions are critical to monitor in older adults due to the high prevalence of polypharmacy in this population. 



    ]]>     Sat, 06 Jun 2026 00:00:00 -0400 https://www.thecarlatreport.com/blogs/1-the-carlat-psychiatry-blog/post/6318-free-sample-section-important-drug-drug-interactions-in-older-adults http://www.thecarlatreport.com/blogs/1/post/6318     Free Sample Table: Hyperbolic Taper for SSRIs If a patient is tapering off SSRIs completely — rather than switching to another antidepressant — a hyperbolic taper minimizes the risk of withdrawal. If a patient is tapering off SSRIs completely — rather than switching to another antidepressant — a hyperbolic taper minimizes the risk of withdrawal.



    ]]>     Sat, 06 Jun 2026 00:00:00 -0400 https://www.thecarlatreport.com/blogs/1-the-carlat-psychiatry-blog/post/6317-free-sample-table-hyperbolic-taper-for-ssris http://www.thecarlatreport.com/blogs/1/post/6317     Free Research Summary: Which Meds Are Best for Panic Disorder (Anxiety and Compulsive Disorder) There are many effective medications for panic disorder, including tricyclic antidepressants (TCAs), selective serotonin reuptake inhibitors (SSRIs), serotonin-norepinephrine reuptake inhibitors (SNRIs), and monoamine oxidase inhibitors (MAOIs). There are many effective medications for panic disorder, including tricyclic antidepressants (TCAs), selective serotonin reuptake inhibitors (SSRIs), serotonin-norepinephrine reuptake inhibitors (SNRIs), and monoamine oxidase inhibitors (MAOIs). 


    ]]>     Sat, 06 Jun 2026 00:00:00 -0400 https://www.thecarlatreport.com/blogs/1-the-carlat-psychiatry-blog/post/6316-free-research-summary-which-meds-are-best-for-panic-disorder-anxiety-and-compulsive-disorder http://www.thecarlatreport.com/blogs/1/post/6316     Free Research Summary: Cannabis Use Frequency and Cannabis Use Disorder (Addiction Psychiatry) Sat, 06 Jun 2026 00:00:00 -0400 https://www.thecarlatreport.com/blogs/1-the-carlat-psychiatry-blog/post/6315-free-research-summary-cannabis-use-frequency-and-cannabis-use-disorder-addiction-psychiatry http://www.thecarlatreport.com/blogs/1/post/6315