https://www.thecarlatreport.com/rss en-us How long should you wait before making changes after initiating an antipsychotic? The current study tested if early efficacy on an antipsychotic predicts subsequent efficacy, and its findings indicate benefits may be observed as quickly as two weeks. 

]]> http://www.thecarlatreport.com/articles/4838 Tue, 01 Oct 2024 00:00:00 -0400 https://www.thecarlatreport.com/articles/4838-how-long-to-wait-before-changing-antipsychotics-in-schizophrenia  The negative symptoms of schizophrenia are notoriously difficult to address with traditional treatments. The meta-analysis suggests TMS can significantly improve negative symptoms and may offer a promising new treatment approach.

]]> http://www.thecarlatreport.com/articles/4837 Tue, 01 Oct 2024 00:00:00 -0400 https://www.thecarlatreport.com/articles/4837-negative-symptoms-of-schizophrenia-a-new-target-for-tms Exercise improves sleep, cognition, and hippocampal volume, but can it enhance exposure-based learning in therapy for PTSD?

]]> http://www.thecarlatreport.com/articles/4825 Thu, 26 Sep 2024 00:00:00 -0400 https://www.thecarlatreport.com/articles/4825-enhancing-ptsd-therapy-with-aerobic-exercise-a-new-approach Finding the right stimulant dose for adult ADHD can be tough. This study looked at how higher doses beyond FDA limits affect symptom control and side effects.

]]> http://www.thecarlatreport.com/articles/4811 Tue, 03 Sep 2024 00:00:00 -0400 https://www.thecarlatreport.com/articles/4811-high-dose-stimulants-in-adult-adhd Conventional wisdom suggests that antipsychotics need similar doses for mania and schizophrenia. This analysis clarifies the exceptions.

]]> http://www.thecarlatreport.com/articles/4783 Thu, 01 Aug 2024 00:00:00 -0400 https://www.thecarlatreport.com/articles/4783-antipsychotic-dosing-differences-between-bipolar-mania-and-schizophrenia Online treatment offers greater access to care for our patients with reduced travel and environmental costs. But is this modality effective? This research update looks at a study in which internet-based cognitive behavioral therapy was used for treating OCD in children and teens.

]]> http://www.thecarlatreport.com/articles/4798 Mon, 01 Jul 2024 00:00:00 -0400 https://www.thecarlatreport.com/articles/4798-ocd-treatment-from-home When we must use antipsychotics (NbN D2 receptor blockers), we do whatever we can to avoid side effects from them. This research upside looks at the potential for the new olanzapine-semiglutide combination medication to reduce D2 blocker-related weight gain in children and teens.

]]> http://www.thecarlatreport.com/articles/4797 Mon, 01 Jul 2024 00:00:00 -0400 https://www.thecarlatreport.com/articles/4797-a-promising-combo-olanzapine-and-samidorphan What is the impact of alcohol use in teens on their risk for developing depression? Spoiler alert: If it were a clear linear relationship, there would be no story here. Read this research update and use it to improve your process for screening for alcohol use.

]]> http://www.thecarlatreport.com/articles/4796 Mon, 01 Jul 2024 00:00:00 -0400 https://www.thecarlatreport.com/articles/4796-alcohol-dependence-in-teens-linked-to-depression-in-young-adults Does physical activity help relieve depression in children and adolescents? We know it helps adults, but what is the evidence in kids? This research update looks at a study that tries to elucidate the effectiveness of exercise on depression in kids and teens, and how much to emphasize exercise with your own patients.

]]> http://www.thecarlatreport.com/articles/4795 Mon, 01 Jul 2024 00:00:00 -0400 https://www.thecarlatreport.com/articles/4795-physical-activity-for-depression-in-youth-a-closer-look-at-the-data This trial tests whether mobile apps improve prospective memory in MCI.

]]> http://www.thecarlatreport.com/articles/4777 Mon, 01 Jul 2024 00:00:00 -0400 https://www.thecarlatreport.com/articles/4777-smartphone-apps-benefit-memory-and-quality-of-life This study compares the MoCA to neuropsychological testing in identifying mild cognitive impairment.

]]> http://www.thecarlatreport.com/articles/4776 Mon, 01 Jul 2024 00:00:00 -0400 https://www.thecarlatreport.com/articles/4776-diagnosing-mild-cognitive-impairment-neuropsych-testing-and-moca-go-head-to-head It was once thought that moderate alcohol intake was protective against cardiovascular disease. However, new research has revealed flaws in the methodology of these old studies and instead finds that even in moderation, alcohol does not have health benefits and can increase mortality at lower doses than once thought, particularly for women.

]]> http://www.thecarlatreport.com/articles/4767 Mon, 01 Jul 2024 00:00:00 -0400 https://www.thecarlatreport.com/articles/4767-daily-alcohol-intake-and-risk-for-all-cause-mortality Everyone knows that it is dangerous to drive while under the influence of alcohol—but what about cannabis? This study adds to a growing body of evidence that cannabis can be hazardous to safety on the road, a particularly important message to get out to patients as legalization becomes increasingly common.

]]> http://www.thecarlatreport.com/articles/4766 Mon, 01 Jul 2024 00:00:00 -0400 https://www.thecarlatreport.com/articles/4766-does-cannabis-legalization-increase-the-risk-of-driving-related-injury Buprenorphine and methadone are both first-line treatments for opioid use disorder during pregnancy. Though this recommendation has been long-standing, it is based on a rather small study that is nearly 15 years old. In the current study, researchers revisit the question of how best to treat opioid use disorder during pregnancy with a large observational cohort study.

]]> http://www.thecarlatreport.com/articles/4765 Mon, 01 Jul 2024 00:00:00 -0400 https://www.thecarlatreport.com/articles/4765-buprenorphine-versus-methadone-for-opioid-use-disorder-in-pregnancy Incorporating a simple and low-cost intervention—aerobic exercise—into cognitive rehabilitation programs for patients with schizophrenia accelerates cognitive gains and improves school and work functioning.

]]> http://www.thecarlatreport.com/articles/4750 Mon, 01 Jul 2024 00:00:00 -0400 https://www.thecarlatreport.com/articles/4750-aerobic-exercise-boosts-cognitive-training-benefits-in-early-schizophrenia The findings of this large study offer some reassurance about the safety and efficacy of antipsychotic polypharmacy, despite general treatment guidelines cautioning against it.

]]> http://www.thecarlatreport.com/articles/4749 Mon, 01 Jul 2024 00:00:00 -0400 https://www.thecarlatreport.com/articles/4749-antipsychotic-polypharmacy-maybe-not-so-risky-after-all This comprehensive study highlights the need for gender-specific treatment in schizophrenia spectrum disorders, revealing that hormonal changes call for lower antipsychotic doses for female patients under 45 and higher doses for those who are post-menopausal.

]]> http://www.thecarlatreport.com/articles/4748 Mon, 01 Jul 2024 00:00:00 -0400 https://www.thecarlatreport.com/articles/4748-does-menopause-increase-risk-of-psychosis Another trial questions the benefits of antipsychotics in delirium.

]]> http://www.thecarlatreport.com/articles/4735 Sat, 01 Jun 2024 00:00:00 -0400 https://www.thecarlatreport.com/articles/4735-does-haloperidol-improve-hospitalization-or-mortality-in-delirium New analysis questions whether STAR*D followed its own protocols.

]]> http://www.thecarlatreport.com/articles/4734 Sat, 01 Jun 2024 00:00:00 -0400 https://www.thecarlatreport.com/articles/4734-memantine-for-trichotillomania-and-excoriation-disorder New analysis questions whether STAR*D followed its own protocols.

]]> http://www.thecarlatreport.com/articles/4733 Sat, 01 Jun 2024 00:00:00 -0400 https://www.thecarlatreport.com/articles/4733-stard-reanalysis-causes-new-debate-over-antidepressant-efficacy Structured approaches for Image Rehearsal Therapy (IRT) and the Cognitive-Experiential Dream Model (CEDM) for tackling nightmares.

]]> http://www.thecarlatreport.com/articles/4709 Tue, 21 May 2024 00:00:00 -0400 https://www.thecarlatreport.com/articles/4709-assessing-our-current-understanding-of-therapy-for-dreams-and-nightmares sleep_GeorgeRudy_shutterstock_2462364013.png This study investigates whether augmenting risperidone with sertraline can improve negative symptoms. 

]]> http://www.thecarlatreport.com/articles/4700 Wed, 01 May 2024 00:00:00 -0400 https://www.thecarlatreport.com/articles/4700-sertraline-in-schizophrenia A look whether administering ketamine during general anesthesia changes its ability to treat depression.

]]> http://www.thecarlatreport.com/articles/4699 Wed, 01 May 2024 00:00:00 -0400 https://www.thecarlatreport.com/articles/4699-ketamine-fails-to-outperform-placebo-for-depression-in-patients-under-anesthesia Researchers delve into the occurrence of mood switches in bipolar disorder, and consider both manic and depressive episodes. 

]]> http://www.thecarlatreport.com/articles/4698 Wed, 01 May 2024 00:00:00 -0400 https://www.thecarlatreport.com/articles/4698-mood-switching-in-bipolar-disorder Night shift work poses significant challenges, with one in five workers experiencing sleep disturbances. A study comparing morning and evening sleep sheds light on managing shift work disorder.

]]> http://www.thecarlatreport.com/articles/4663 Mon, 01 Apr 2024 08:06:48 -0400 https://www.thecarlatreport.com/articles/4663-optimizing-sleep-timing-for-night-shift-workers yawn_shutterstock_3006765_AdamMiddleton.png One mood stabilizer stands out for its lower risk of mortality in bipolar disorder.

]]> http://www.thecarlatreport.com/articles/4666 Mon, 01 Apr 2024 01:00:00 -0400 https://www.thecarlatreport.com/articles/4666-do-mood-stabilizers-prevent-death-in-bipolar-disorder In MCI or dementia, CBT is the only psychological intervention that improves depression, quality of life, and ADLs.

]]> http://www.thecarlatreport.com/articles/4728 Mon, 01 Apr 2024 00:00:00 -0400 https://www.thecarlatreport.com/articles/4728-therapy-in-dementia-choose-cbt Drinking a proprietary ketogenic drink appears to improve cognition in mild cognitive impairment.

]]> http://www.thecarlatreport.com/articles/4727 Mon, 01 Apr 2024 00:00:00 -0400 https://www.thecarlatreport.com/articles/4727-can-a-ketogenic-drink-improve-cognition-in-mild-cognitive-impairment How do lithium and quetiapine compare in their ability to treat acute mania in children and teens? Are they effective? Do kids go into remission? And how do their side effect profiles compare?  This clinical update can help you decide which patients might be good candidates for which medication. 

]]> http://www.thecarlatreport.com/articles/4716 Mon, 01 Apr 2024 00:00:00 -0400 https://www.thecarlatreport.com/articles/4716-lithium-vs-quetiapine-for-acute-mania-in-youth You want to protect your manic child or teen patient from metabolic problems associated with most antipsychotics, so you think about using ziprasidone. How likely is it to work? Is it truly well tolerated? We give you our best take on it despite the problems inherent in industry-funded research. 

]]> http://www.thecarlatreport.com/articles/4715 Mon, 01 Apr 2024 00:00:00 -0400 https://www.thecarlatreport.com/articles/4715-ziprasidone-for-mania-in-bipolar-i-disorder-in-children-and-teens