Ask The Editor

Wellbutrin Augmentation: When Does It Work?

Topics: Depression | Treatment-Resistant Depression | Wellbutrin

Each month, Editor-in-Chief Chris Aiken, MD, gives advice on a different practice challenge. Dear Dr. Aiken: In the July/August 2018 issue, you wrote that ­bupropion (Wellbutrin) augmentation does not work in ­treatment-resistant depression (TRD). So why do we see it work so often in practice? Dr. Aiken: When all of the studies are averaged tog

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Research Update

Is Ketamine Just Another Opiate?

Topics: Antidepressants | Depression | Ketamine | Opioids | Research Update

Review of: Williams NR et al, Am J Psychiatry 2018;175:1–11 Type of study: Double-blind, placebo-controlled, crossover study Ketamine’s rapid antidepressant effects have now been demonstrated in over two dozen double-blind, placebo-controlled trials, but how it works is less clear. For many years, NMDA receptor antagonism was thought responsib

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Expert Q&A

Benefits of Alpha-Stim