Clinical Update

Tricyclic Antidepressants: When and How to Use Them

Topics: Antidepressants | Dosing | Side Effects | Treatment-Resistant Depression | Weight gain

Tricyclics have been used in psychiatry since the 1950s, when imipramine was introduced as the first mass-marketed antidepressant. Fluoxetine and the other SSRIs largely supplanted the tricyclics in the 1990s, but these medications still have their uses.  There are two kinds of tricyclics:  Tertiary amines—the “originals” Secondary amines—t

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Research Update

Establishing a Dose-Response Relationship for Lurasidone in Acute Schizophrenia

Topics: Antipsychotics | Dose Response | Dosing | Lurasidone | Schizophrenia

REVIEW OF: Srisurapanont M et al, Sci Rep 2021:11(1):5571 STUDY TYPE: Network meta-analysis Lurasidone is FDA approved in schizophrenia, but we lack good evidence to guide its dosage. This study compared the efficacy, safety, and acceptability of lurasidone at different doses to establish a dose-response relationship for its therapeutic and adverse ef

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