Mood

Research Update

Can We Treat Depression by Targeting Inflammation?

Topics: Antibiotic | Depression | Inflammation | Minocycline | Mood | Pharmacotherapy

REVIEW OF: Zazula R et al, Aust N Z J Psychiatry 2021;55(8):784–798 Recent data suggest inflammation may play a role in depression, prompting research into the efficacy of minocycline—a tetracycline antibiotic with anti-inflammatory effects—as an augmentation agent in the treatment of major depressive disorder (MDD). This study was a pooled

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Research Update

Psilocybin: The New Holy Grai­l for the Rapid Relief of Major ­Depression?

Topics: Depression | Ketamine | Mood | Pharmacotherapy | Psilocybin | Rapid-acting

Review of: Davis AK et al, JAMA ­Psychiatry 2020:e203285 Intravenous ketamine and intranasal esketamine (Spravato) offer hope in the search for a rapidly acting antidepressant. However, concerns regarding addiction, safety, and effect durability have prompted searches for alternative rapid-acting treatments. Psilocybin is a hallucinogen originally d

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Expert Q&A

How to Diagnose Bipolar Disorder

Topics: Bipolar Depression | Bipolar Disorder | Bipolar II | Diagnosis | DSM | Hypomania | Mania | Mixed Features | Mood

TCPR: When I ask a depressed patient if they’ve ever had manic symptoms, I often run into a problem. They say, “Of course I feel more confident, energetic, and happy ... when I’m not depressed.”Dr. Parker: As it can be hard to tease apart true hypomania from normal happiness, we’ve developed a rating scale to assist, the Sydney Bipolar Screene

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