Opioid antagonist

Research Update

New Combination Treatment Mitigates Antipsychotic-Induced Weight Gain

Topics: Metabolic syndrome | olanzapine | Opioid antagonist | Samidorphan | Schizophrenia | Weight gain

Review of: Correll CU et al, Am J Psychiatry 2020;177(12):1168–1178 To date, we have had no FDA-approved medications to mitigate antipsychotic-­associated weight gain (AIWG). This will soon change, thanks to recent research showing that samidorphan, an opioid receptor antagonist, appears to significantly lessen weight gain associated with the use

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