Pharmacology

Article

A Second Look at Genetic Testing

Topics: GeneSight | Genetic Testing | Pharmacology

Genetic tests are marketed with a bold claim: that a handful of genes can predict medication response. AssureRx’s GeneSight is the most popular of these tests, and in 2015 we reviewed the evidence behind its panel. In short, it was lacking, but the company has just released new data that may move it a little closer to the mainstream. What’s

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Article

Ask the Editor: Should You Prescribe Lithium to Suicidal Patients?

Topics: Lithium | Pharmacology | Suicidality

Dear Dr. Aiken: You recommended lithium for suicidal patients in the TCPR 2018 summer issue, but isn’t there a risk of overdose with this strategy? Dr. Aiken: From firearms to bridges, the suicide rate goes down when we erect barriers to the means. Barriers work because suicidal impulses are brief, lasting only 1–2 hours on average. It

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Article

Benzodiazepines in Children and Adolescents

Topics: Benzodiazepines | Child Psychiatry | Pharmacology

Michael, who’s 9, is brought in by his parents for his first psychiatric assessment. His parents report that lately, Michael has been worrying all the time. He asks to sleep in his parents’ bed. This past month, he also began having problems separating from his parents in the morning for school. Michael’s therapist suggested a medication assessmen

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Tales From History

The History of Depakote

Topics: Pharmacology

Valproate originally saw the light of day in the German laboratory of Beverly Burton, in 1882. She was engaged in research on fatty acids, and synthesized a new one, called 2-propylvaleric acid. But she was not able to make this acid into a salt, which is necessary in order to turn it into a solid form, and so she stopped working on it. The compound res

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