Pregnancy

Article

Breast-feeding and Antidepressants: An Update

Topics: Antidepressants | Pregnancy | SSRIs

There’s nothing like a close friend suffering psychiatric difficulties to motivate a psychiatrist to do some serious reading. Recently, your humble editor encountered this situation. The patient is a young woman with no psychiatric history who noted more than a normal amount of anxiety after the birth of her child. She found herself worrying consta

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Article

SSRIs in Pregnancy: Third Trimester Concerns

Topics: Pregnancy | SSRIs

You may not know it, but this year marks a milestone in the world of SSRI teratology research. Ten years ago, JAMA published the first controlled study of Prozac exposure in pregnancy (1). The results? Neither Prozac nor tricyclics caused more birth defects than controls, but both antidepressants caused more neonatal complications. Ten years later, w

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Expert Q&A

Dr. Victoria Hendrick on Using Meds in Pregnancy

Topics: Antidepressants | Pregnancy | SSRIs

TCR: Dr. Hendrick, there has been a lot of confusing and seemingly contradictory data about the safety of SSRIs during pregnancy. What’s your take? Dr. Hendrick: You’re right, it is confusing, but one reassuring and important point is that there is no evidence that the SSRIs or any other antidepressant are linked to an increased risk of congenital

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Anecdotes From The Field

An OB/GYN Perspective

Topics: Antidepressants | Pregnancy | SSRIs

Roseann Gumina, M.D., is an obstetrician/gynecologist in private practice in Milwaukee, Wisconsin. Like most OB/GYNs, Dr. Gumina sees more pregnant women on antidepressants in a given year than most psychiatrists are likely to see in a lifetime, and her perspective is informative. “Generally, most women who have been on SSRIs will have already disc

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News of Note

Brexanolone (Zulresso) for Postpartum Depression

Topics: Depression | Depressive Disorder | Pharmacology | Postpartum Depression | Pregnancy

On March 19, 2019, the FDA approved brexanolone (Zulresso), the first medication for postpartum depression (PPD). Delivered by intravenous injection, brexanolone is an analogue of the hormone allopregnanolone. Allopregnanolone levels fall abruptly after childbirth, which is thought to contribute to PPD by destabilizing GABAA receptors. We covered brexa

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Expert Q&A

What Can Our Pregnant Patients Do to Prevent Mental Illness in Their Children?

Topics: Practice Tools and Tips | Pregnancy

TCPR: Expectant mothers often want to come off psychiatric medications. From their perspective, mental illness takes place in the brain and won’t affect the fetus, while psychiatric medications are quite dangerous. What can we tell them?Dr. Freedman: There are risks with psychiatric medications, but the only one that is contraindicated in pregnancy

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