Psychotic Depression

In Brief

In Brief: What Causes Affective Psychosis?

Topics: Psychosis | Psychotic Depression

Psychotic depression and bipolar disorder are sometimes lumped together as the “affective psychoses.” Among the mood disorders, these two have a stronger biological basis, although environmental causes still contribute to their risk. In a meta-analysis of 68 studies (Rodriguez V et al, Schizophr Bull 2021 Jan 22:sbaa197), 6 environmental risk fact

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Research Update

Are SSRIs Associated With Increased Rates of Violence?

Topics: Deprescribing | Mania on Antidepressants | Medication adherence | polypharmacy | Psychosis | Psychotic Depression | Schizophrenia | Tags | Tardive dyskinesia | Withdrawal

REVIEW OF: Lagerberg et al, Eur Neuropsychopharm 2020;26:1–9 TYPE OF STUDY: Analysis of Swedish national registries Soon after the introduction of SSRIs in 1988, case reports began to emerge suggesting that they might trigger violence in a small subset of patients. At the time, such reports were mostly dismissed and attributed to the fact that p

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Clinical Update

Modern Challenges of Delusional Disorder

Topics: Antipsychotics | Delusional Disorder | Pimozide | Psychosis | Psychotic Depression

While positive symptoms like hallucinations and delusions are among the more treatment-responsive symptoms of schizophrenia, the treatment of delusional disorder often proves much more vexing. Delusional disorder is often a diagnosis of exclusion requiring that you rule out other causes like schizophrenia, primary mood disorder, or substance-induced ps

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Research Update

An Answer for Psychotic Depression

Topics: Antidepressants | Antipsychotics | Deprescribing | Depression | Depressive Disorder | olanzapine | Pharmacology | Pharmacology Tips | Psychosis | Psychotic Depression | Research | Research Update | Tardive dyskinesia

REVIEW OF: Flint AJ et al, JAMA 2019;322(7):622–631 TYPE OF STUDY: Randomized, placebo-controlled trial Psychotic features in depression indicate a more severe form of the disease, with a higher risk of hospitalization and double the rate of disability compared with non-psychotic depression. A combination of an antipsychotic and an antidepressant is

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