Randomized controlled trial

Clinical Update

Reading Research: Details Matter

Topics: adverse events | control group | double blind | effect size | NNH | NNT | null hypothesis | number needed to harm | number needed to treat | Open Label | p-value | primary outcome | Randomized controlled trial | randomized discontinuation design | RCT | replication | secondary outcome | statistical significance | treatment efficacy | unblinded

When headlines report on positive treatment results from a study, families will come in asking about those results. This article will help you determine what makes a study a good one, and conversely what makes a not-so-great one. With this information, you can be better prepared to talk with families about research studies and results that can affect tr

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Research Update

Do We Need to Be Face-to-Face to Treat Alcohol Use Disorder?

Topics: Alcohol use disorder | Quality of care | Randomized controlled trial | Telemedicine

Review of: Johansson M et al, Addiction 2020 Sep 24. Epub ahead of print. The COVID-19 pandemic has highlighted the potential value of virtual treatment. This may be particularly useful for individuals with alcohol use disorder (AUD), for whom shame and stigma may limit engagement and/or retention in traditional forms of face-to-face treatment. Howev

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Research Update 1

Can Assertive Treatment Improve Treatment Adherence in Young Adults With Opioid Use Disorder?

Topics: Adherence | Opioid Use Disorder | Randomized controlled trial | Youth

Review of: Fishman M et al, Addiction 2020 Jul 4. https://doi.org/10.1111/add.15181 We often use injectable extended-release naltrexone (XR-NTX, or Vivitrol) for management of opioid use disorder (OUD). However, XR-NTX has not been widely used in young adults with OUD, possibly due to low patient engagement and treatment adherence. This study evaluat

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Research Update

Genetic Testing in Depression

Topics: GeneSight | Genetic Testing | Genetics and Psychiatry | Pharmacogenomics | Randomized controlled trial | Research | Research Update

REVIEW OF: Perlis RH et al, Depress Anxiety 2020;37(9):834–841 STUDY TYPE: Randomized controlled trial By tailoring medications to a patient’s genetic profile, pharmacogenomics promises less medication trial and error, fewer side effects, and better overall outcomes. But does knowing a patient’s pharmacogenetic profile really improve treatment f

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Research Update

Two Negative Studies of Mirtazapine and Riluzole for PTSD in Veterans

Topics: Mirtazapine | PTSD | Randomized controlled trial | Research | Research Update | Riluzole | Trauma

Review of: Davis LL et al, J Clin Psychiatry 2020;81(6):20m13267; Spangler PT et al, J Clin Psychiatry 2020;81(6):20m13233 Type of Studies: Randomized, placebo-controlled trial; randomized controlled trial Medications for posttraumatic stress disorder (PTSD) don’t have a great track record, particularly in combat-related trauma. Prazosin, risperid

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Research Update

Shining a Light on PTSD

Topics: Complementary treatments | Light therapy | Lightbox | natural treatments | PTSD | Randomized controlled trial | Research | Research Update | Seasonal Affective Disorder | Trauma

Review of: Youngstedt SD et al, Mil Med 2021 (Epub ahead of print) Study type: Randomized, sham-controlled trial As stated in the previous brief, PTSD is difficult to treat, and numerous interventions for PTSD have failed with veterans. This study took a different approach; it is the first randomized controlled trial of light therapy for PTSD. Conduc

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