Research Update

Research Update

How Effective Are Medications for Pediatric Anxiety?

Topics: Anxiety | Research Update

Review of: Strawn JR et al, J Am Acad Child Adolesc Psychiatry 2018;57(4):235–244.e2 Antidepressants are part of the first-line treatment for severe childhood anxiety disorders when removal of stressors and psychotherapy are not enough, but are all antidepressants created equal in this situation? A recent meta-analysis shows that antidepressants

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Research Update

Cannabidiol for Schizophrenia

Topics: Cannabidiol | Research Update | Schizophrenia

Review of: McGuire P et al, Am J Psychiatry 2017;175(315). doi:10.1176/appi.ajp.2017.17030325 Type of study: Double-blind, randomized controlled trial Traditional antipsychotic medications leave much to be desired. Their therapeutic response rate for schizophrenia is low, and their side effects are troubling and lead to high rates of noncompliance

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Research Update

Is Ketamine Just Another Opiate?

Topics: Antidepressants | Depression | Ketamine | Opioids | Research Update

Review of: Williams NR et al, Am J Psychiatry 2018;175:1–11 Type of study: Double-blind, placebo-controlled, crossover study Ketamine’s rapid antidepressant effects have now been demonstrated in over two dozen double-blind, placebo-controlled trials, but how it works is less clear. For many years, NMDA receptor antagonism was thought responsib

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Research Update

Suicide Rates in College Students

Topics: Research Update

Review Of: Mortier P, J Am Acad Child Adolesc Psychiatry 2018;57(4):263–27 Adolescence is a time of high risk for suicidal thoughts and behaviors (STB), and rates are rising. In those ages 15–29, suicide is the second leading cause of death globally (http://www.who.int/mental_health/prevention/suicide/suicideprevent/en). A recent article publishe

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Research Update

More Evidence of Lives Saved by Medications for Opioid Use Disorder

Topics: Opioids | Research Update

REVIEW OF: Larochelle MR et al, Ann Intern Med 2018;169(3):137–145 We are in the middle of an opioid crisis in the US, with many lives lost daily to opioid-related deaths. Pharmacotherapy with methadone, buprenorphine, or naltrexone represents an important tool for clinicians during this crisis. But just how good are these medications in saving liv

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Research Update

Probiotics for Bipolar Disorder

Topics: Bipolar Disorder | Research Update

Review of: Dickerson F et al, Bipolar Disord 2018. doi:10.1111/bdi.12652 [Epub ahead of print] Type of study: Randomized double-blind placebo-controlled trial Probiotics, the so-called “good” bacteria in the gut flora, have become popular as a natural treatment for various disorders. They are taken as capsules or through food sources like yogu

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Research Update

Does TMS Really Work in Depression?

Topics: Depressive Disorder | Research Update

Review of: Yesavage et al, JAMA Psychiatry 2018;75(9):884–893 Type of study: Randomized, sham-controlled trial Repetitive transcranial magnetic stimulation (rTMS) has been FDA-approved for treatment-resistant depression (TRD) since 2008. This non-invasive therapy uses an electromagnetic coil to stimulate electrical activity in the frontal cortex

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Research Update

Is Cannabis Bad for Cognition?

Topics: Research Update | Substance Abuse

Review of: Cobb SJ et al, JAMA Psychiatry 2018;75(6):585–595 Our patients typically tell us that, according to the internet, weed is perfectly safe and does not affect their ability to think or function. Thirty states and the District of Columbia have laws legalizing cannabis, supporting the notion that people have begun to think of marijuana as re

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Research Update

Is Clozapine the Next Step After a Single Failed Antipsychotic Trial?

Topics: Antipsychotics | Research Update

Review of: Khan RS et al, Lancet Psychiatry, published online 8/13/2018 Type of study: Sequential trial with open-label and randomized, double-blind comparison phases Clozapine is often used as a last resort in schizophrenia, even though practice guidelines recommend a trial of this medication after failing 2 antipsychotics. The current study set

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Research Update

Opioids Not Superior to Other Medicines for Some Chronic Pain

Topics: Addiction | Research Update | Substance Abuse

REVIEW OF: Krebs EE et al, JAMA 2018;319(9):872–882 Rising rates of opioid overdose deaths have sounded alarm bells over opioid prescribing practices for chronic pain. Unfortunately, and despite the absence of quality data on their risks vs benefits, long-term opioid management has remained a common approach to managing chronic musculoskeletal pain

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Research Update

Effects of Cannabis Use on Smoking Cessation

Topics: Research Update | Smoking Cessation | Substance Abuse

REVIEW OF: Weinberger AH et al, J Clin Psychiatry 2018;79(2):17m11522 When counseling your patients to quit smoking, you may also want to consider asking them about their past marijuana use. Results from a recent study suggest that there may be a correlation between cannabis and tobacco smoking. Analysis of longitudinal data of almost 35,000 adult

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Research Update

Are All Psychotherapies for Anorexia Created Equal?

Topics: Research Update

Review of: Zeeck A et al, Front Psychiatry 2018;9:158. doi:10.3389/fpsyt.2018.00158 Type of study: Meta-analysis of randomized controlled trials Psychotherapy is the main treatment for anorexia nervosa, but which type works best? Several therapies have good evidence in this population, but they differ in their models and methods, and head-to-head

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Research Update

CBT vs Pharmacotherapy for Childhood Anxiety

Topics: Depressive Disorder | Research Update

Review of: Wang Z et al, JAMA Pediatr 2017;171(11):1049–1056 Managing childhood anxiety can sometimes leave clinicians in a quandary. There is a paucity of evidence comparing different treatment approaches, and current guidelines on the subject are old and make inconsistent recommendations. To address this dilemma, researchers at the Mayo Clinic pe

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Research Update

Amphetamine Extended Release Oral Suspension for ADHD

Topics: ADHD | Research Update

Review of: Childress AC et al, J Child Adolesc Psychopharmacol 2017;28(5):306–313 In 2015, the FDA approved Dyanavel XR (amphetamine extended release oral suspension), which was the first long-acting liquid version of amphetamine on the market. To provide some context, Quillivant XR, a long-action liquid methylphenidate formulation, was approved in

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Research Update

Serotonin Syndrome Risks With Co-Prescription of Triptan Drugs and SSRIs or SNRIs

Topics: Depressive Disorder | Research Update

Review of: Orlova Y, JAMA Neurology 2018;E1–E7 In 2006, the FDA issued a warning that patients using either selective serotonin reuptake inhibitors or selective norepinephrine reuptake inhibitors (SSRIs or SNRIs) together with triptan antimigraine drugs might be at a heightened risk for serotonin syndrome. Their advisory was based on 27 case report

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Research Update

Mindfulness Therapy for Adult ADHD

Topics: ADHD | Research Update

Review of: Janssen L et al, Psychological Medicine 2018;28:1–11 Medications are the first-line treatment for adult ADHD, and the efficacy of psychosocial therapies is less well-defined. Mindfulness-based therapy showed promise for adult ADHD in a recent meta-analysis, but there were flaws and significant differences between the included studies (Ja

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Research Update

Resilience Networks in Adolescent Females at Risk for Major Depression

Topics: Child Psychiatry | Research Update

Review of: Fischer AS et al, JAMA Psychiatry 2018;75(5):493–502 One of our biggest in-office challenges is how to enhance teen resilience, the process of adapting to and recovering from stressful life experiences. Some neuroscientists hypothesize that resilience is related to the limbic system, which plays a vital role in emotion processing, motiva

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Research Update

Can Computerized Interventions Reduce Cannabis Use?

Topics: Research Update | Substance Abuse

REVIEW OF: Olmos A et al, Addict Behav 2018;79:52–60 As medical and recreational marijuana become legalized in more states, more emphasis is being placed on treatment of those with cannabis use disorders. But with our clinics already at capacity, how can we find the most efficient way of providing therapy? Computerized interventions are already ava

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Research Update

Substance Use Disorders Are Under-Recognized in Patients With Diabetes

Topics: Research Update

REVIEW OF: Wu LT et al, Drug and Alcohol Dep 2018;186:86–93 Type 2 diabetes (T2D) is a common condition with high treatment costs and significant morbidity and mortality. In 2015, an estimated 30.2 million American adults had T2D. Diabetes can be comorbid with other behavioral health disorders (BHDs), and this can lead to additional costs and incre

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Research Update

A CBT App for Refractory Depression

Topics: Research Update

Review of: Mantani A et al, J Medical Internet Res 2017;19(11):e373 Mobile phones have allowed the introduction of guided, self-help cognitive behavioral therapy (CBT) for depression with enhanced accessibility, efficiency, and affordability. Several meta-analyses suggest that computers can augment face-to-face psychotherapy and even work on their ow

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