Research Update

Research Update

Cannabidiol Could Alleviate Psychotic Symptoms in Schizophrenia

Topics: Antipsychotics | Research Update

REVIEW OF: Leweke FM et al, Transl Psychiatry 2012;2:e94 Research has shown that heavy cannabis use is associated with new-onset psychosis, so a study exploring the drug’s use as a treatment for schizophrenia is surprising, to say the least. Recall that cannabis is composed of more than 100 compounds, and that delta-9-tetrahydrocannabinol (THC) is

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Research Update

A Cautionary Consensus on the Use of Ketamine for Depression

Topics: Antidepressants | Depressive Disorder | Research Update

Review of: Sanacora G et al, JAMA Psychiatry 2017;74(4):399–405. doi:10.1001/jamapsychiatry.2017.0080 Ketamine has become increasingly popular as an off-label medication for rapid onset treatment of refractory depression. Recently, the American Psychiatric Association convened a task force to review the data and come up with some recommendations. T

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Research Update

Is Modafinil an Effective Alternative for the Treatment of ADHD?

Topics: ADHD | Child Psychiatry | Research Update

Review of: Wang SM et al, J Psychiatr Res 2017;84:292–300. Modafinil (Provigil) is FDA-approved for narcolepsy, obstructive sleep apnea, and shift work sleep disorder, but not for ADHD. Given that it has some of the same stimulating properties of psychostimulants, it should theoretically be effective. Wang and colleagues identified five randomized

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Research Update

Can Strattera Improve Reading Skills in Children With Dyslexia?

Topics: Child Psychiatry | Research Update

Review of: Shaywitz S et al, J Child Adolesc Psychopharmacol 2016;27(1):19–28. Dyslexia, a learning disability characterized by difficulty in reading skills, is highly prevalent, with rates between 5% and 17%. Treatments include non-medical interventions, which have limited success. Research suggests a critical role for attentional mechanisms in th

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Research Update

How Effective Is Tramadol for Opioid Withdrawal?

Topics: Addiction | Pharmacology Tips | Research Update | Substance Abuse

Review of: Dunn K et al, JAMA Psychiatry 2017. doi:10.1001/jamapsychiatry.2017.1838. [Epub ahead of print] Opioid withdrawal protocols often rely on a buprenorphine taper, but other medications are regularly used either in addition to or in the place of buprenorphine. In particular, tramadol ER, a mild opiate, may be effective and was recently studie

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Research Update

Understanding Tantrums in Autism Spectrum Disorder

Topics: Autism Spectrum Disorder | Child Psychiatry | Research Update

Review of: Mayes S et al, J Dev Phys Disabil 2017;29(4):587–596 Why do children with autism spectrum disorder (ASD) have tantrums? One theory is that these tantrums are due in part to children’s frustration with not being able to express themselves. This theory has led to a treatment approach called “mand training.” A mand is a verbal request

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CME Post-Test

Take The CME Post-Test for ADHD in Children and Adolescents, CCPR, September/October 2017

Topics: ADHD | Autism Spectrum Disorder | Child Psychiatry | Research Update

The post-test for this issue is available for one year after the publication date to subscribers only (October 31, 2018). By successfully completing the test you will be awarded a certificate for 2 CME credits. Click here to take your CME test. Note: All of the CME tests are available in the “My Account” section of the site when you are logge

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CME Post-Test

Take The CME Post-Test for Detox, CATR, September/October 2017

Topics: Addiction | Pharmacology Tips | Psychotherapy | Research Update | Substance Abuse

The post-test for this issue is available for one year after the publication date to subscribers only (December 31, 2017). By successfully completing the test you will be awarded a certificate for 2 CME credits. Click here to take your CME test. Note: All of the CME tests are available in the “My Account” section of the site when you are logg

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Research Update

Defining a Role for Nutrition in Managing Children With ADHD

Topics: ADHD | Child Psychiatry | Research Update

Review of: Lange KW et al, Curr Psychiatry Rep 2017;19(2):8. Parents of kids with ADHD often ask about the role of diet and nutrition in their child’s symptoms, and research has uncovered some interesting possibilities. For example, there is some evidence that concentrations of long-chain polyunsaturated fatty acids (LC-PUFAs, which includes omega-

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Research Update

Is Minocycline Effective When Added to Risperidone for Autism Spectrum Disorder?

Topics: Autism Spectrum Disorder | Child Psychiatry | Research Update

Review of: Ghaleiha A et al, J Child Adolesc Psychopharmacol 2016;26(9): 784–791. The only medication treatments approved for autism spectrum disorder (ASD) are the antipsychotics risperidone and aripiprazole, which are indicated specifically to manage irritability associated with ASD. There’s been some interest in minocycline, which is a second-

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Research Update

Do Prizes for Abstinence Increase Sobriety in People With Serious Mental Illness?

Topics: Research Update

Review of: McDonell MG et al, Am J Psychiatry 2017;174(4):370–377. doi:10.1176/appi.ajp.2016.16050627. Although studies have demonstrated the effectiveness of contingency management (CM) for illicit drug use, there’s less evidence for treatment of alcoholism—in part because a standard breathalyzer has a short detection window of 12 hours, meani

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Research Update

MOXO-CPT: Short and Sweet, but Is It Useful?

Topics: ADHD | Research Update

Review of: Berger I et al, Arch Clin Neuropsychol 2017;32:81–93. Diagnosing ADHD continues to be difficult, time-consuming, and expensive. Having an “objective,” valid test for ADHD would be of value to clinicians and families alike. Continuous performance tests (CPT) are gaining popularity as a complement to clinical examination, rating scales

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Research Update

Can a One-Week Naltrexone Detox Reduce Outpatient Opioid Relapse Rates?

Topics: Addiction | Psychopharmacology | Research Update | Substance Abuse

Review of: Sullivan M et al, Am J Psychiatry 2017; Epub ahead of print. Study Type: Randomized, open-label, parallel-groups trial Naltrexone is an opioid blocker that is FDA-approved for the treatment of alcoholism. However, it is also effective off-label for treating opioid use disorder. The medication comes in two forms: an oral pill (brand name

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Research Update

Computer Games: Good for Cognitive Disorders?

Topics: Research Update

Review of: Hill N et al, Am J Psychiatry 2017;174(4):329–340. Study Type: Systematic review and meta-analysis of randomized controlled trials Can patients train their way to better cognition? We’ve all seen the ads from companies such as Lumosity implying that fun, computer-based learning games will help your mind work better. Such methods are

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Research Update

SSRIs and Bipolar Switching: Evidence of Safety

Topics: Research Update

REVIEW OF: Altshuler L et al, Am J Psychiatry 2017;174(3):266–276. doi:10.1176/appi.ajp.2016.15040558 STUDY TYPE: Randomized, double-blind, multi-site comparison Do antidepressants cause bipolar II patients to switch from depression to hypomania? It’s a controversial question, and you’ll find academic psychiatrists who will argue passionatel

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Research Update

Does CBT Improve Outcome in Buprenorphine Treatment?

Topics: Psychopharmacology | Psychotherapy | Research Update

Patients receiving buprenorphine for opioid use disorder are typically also referred for psychotherapy, either individual or group. However, several studies have failed to show that therapy improves outcomes in buprenorphine treatment program Review of: Moore B et al. Cognitive behavioral therapy improves treatment outcomes for prescription opioid us

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Research Update

Switching Antidepressants May Be No Better Than Staying the Course

Topics: Depressive Disorder | Practice Tools and Tips | Research Update

Review of: Bschor T, Kern H, Henssler J, Baethge C. Switching the antidepressant after nonresponse in adults with major depression: A systemic literature search and meta-analysis. J Clin Psychiatry 2016. doi:10.4088/JCP.16r10749. [Epub ahead of print] Study type: Meta-analysis Clinical trials have shown that the response rate of major depression t

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CME Post-Test

CME Post-Test - Street Drugs, CATR, March/April 2017

Topics: Addiction | Practice Tools and Tips | Psychopharmacology | Psychotherapy | Research Update | Substance Abuse

The post-test for this issue is available for one year after the publication date to subscribers only (December 31, 2017). By successfully completing the test you will be awarded a certificate for 2 CME credits. Click here to take your CME test. Note: All of the CME tests are available in the “My Account” section of the site when you are log

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Research Update

Cannabis and Psychosis: The Debate Continues

Topics: Research Update

Cannabis users seem to be at higher than normal risk to develop psychotic symptoms (see CATR, March 2015, “High Potency Cannabis Increases Risk of First Episode Psychosis”), but so far researchers haven’t solved the chicken-and-egg problem. Studies Reviewed: Schoeler T et al. Effects of continuation, frequency, and type of cannabis use on rela

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Research Update

N-acetylcysteine Shows Promise in Treatment of Co-Occurring PTSD and SUD

Topics: Research Update

Review of: Back SE et al. A double-blind, randomized, controlled pilot trial of N-acetylcysteine in veterans with post traumatic stress disorder and substance use disorder. J Clin Psychiatry, dx.doi.org/10.4088/JCP.15m10239. Study type: Double-blind, ­randomized, controlled trial Post-traumatic stress disorder (PTSD) is the most common psychiatri

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