Research Update

Research Update

Switching Antidepressants May Be No Better Than Staying the Course

Topics: Depressive Disorder | Practice Tools and Tips | Research Update

Review of: Bschor T, Kern H, Henssler J, Baethge C. Switching the antidepressant after nonresponse in adults with major depression: A systemic literature search and meta-analysis. J Clin Psychiatry 2016. doi:10.4088/JCP.16r10749. [Epub ahead of print] Study type: Meta-analysis Clinical trials have shown that the response rate of major depression t

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CME Post-Test

CME Post-Test - Street Drugs, CATR, March/April 2017

Topics: Addiction | Practice Tools and Tips | Psychopharmacology | Psychotherapy | Research Update | Substance Abuse

The post-test for this issue is available for one year after the publication date to subscribers only (December 31, 2017). By successfully completing the test you will be awarded a certificate for 2 CME credits. Click here to take your CME test. Note: All of the CME tests are available in the “My Account” section of the site when you are log

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Research Update

Cannabis and Psychosis: The Debate Continues

Topics: Research Update

Cannabis users seem to be at higher than normal risk to develop psychotic symptoms (see CATR, March 2015, “High Potency Cannabis Increases Risk of First Episode Psychosis”), but so far researchers haven’t solved the chicken-and-egg problem. Studies Reviewed: Schoeler T et al. Effects of continuation, frequency, and type of cannabis use on rela

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Research Update

N-acetylcysteine Shows Promise in Treatment of Co-Occurring PTSD and SUD

Topics: Research Update

Review of: Back SE et al. A double-blind, randomized, controlled pilot trial of N-acetylcysteine in veterans with post traumatic stress disorder and substance use disorder. J Clin Psychiatry, dx.doi.org/10.4088/JCP.15m10239. Study type: Double-blind, ­randomized, controlled trial Post-traumatic stress disorder (PTSD) is the most common psychiatri

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Research Update

Internet-Delivered CBT for Adolescents With OCD

Topics: Child Psychiatry | OCD | Research Update

Study Reviewed: Lenhard F et al. Therapist-guided, Internet-delivered cognitive-behavioral therapy for adolescents with obsessive-compulsive disorder: A randomized controlled trial. J Am Acad Child Adolesc Psychiatry 2017;56(1):10–19. doi:10.1016/j.jaac.2016.09.515 Study Type: Randomized controlled trial The prevalence of obsessive-compulsive di

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Research Update

Can a 10-Minute Intervention Improve Sleep in Children With ADHD?

Topics: ADHD | Child Psychiatry | Research Update

Study Reviewed: Peppers K et al. An intervention to promote sleep and reduce ADHD symptoms. Journal of Pediatric Healthcare 2016;30(6):43–48. Study Type: Open, uncontrolled clinical trial We know that kids with ADHD often have sleep issues, and that the stimulants we use to treat them can cause insomnia. What would happen if we focused our treat

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Research Update

Statins and SSRIs Together Lead to Better Outcomes in Depression

Topics: Depression | Research Update

Review of: Köhler O, Gasse C, Petersen L, et al. The effect of concomitant treatment with SSRIs and statins: a population-based study. American Journal of Psychiatry 2016;173(8):807–815. Study Type: Naturalistic cohort study Is depression a disorder of inflammation? This intriguing hypothesis has been floating around in the literature over the

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Research Update

E-Cigarette Use Increases Quit Rates in England

Topics: Research Update

Review of: Beard E, West R, Michie S, et al. Association between electronic cigarette use and changes in quit attempts, success of quit attempts, use of smoking cessation pharmacotherapy, and use of stop smoking services in England: time series analysis of population trends. British Medical Journal 2016;354:i4645. STUDY TYPE: Time series analysis

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Research Update

Heavy Alcohol Use and History of Alcohol Dependence Lead to Cognitive Problems Later in Life

Topics: Research Update

Review of: Woods AJ, Porges EC, Bryant VE, et al. Current heavy alcohol consumption is associated with greater cognitive impairment in older adults. Alcoholism: Clinical and Experimental Research 2016; ahead of publication. STUDY TYPE: Quasi-experimental study There are a few truths when it comes to cognitive functioning and acute alcohol use. We

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Research Update

SSRIs May Work More Quickly in Pediatric OCD Than You Realize

Topics: Research Update

Review of: Varigonda A et al. Journal of the American Academy of Child & Adolescent Psychiatry 2016; ahead of publication. Study Type: Systematic literature review and meta-analysis The pharmacological treatment of obsessive-compulsive disorder (OCD) for adults is pretty well worked out. Selective serotonin reuptake inhibitors (SSRIs) are the

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Research Update

Metformin Use in Autistic Children Taking Atypical Antipsychotics

Topics: Autism Spectrum Disorder | Research Update

Review of: Anagnostou E, Aman MG, Handen BL, et al. JAMA Psychiatry 2016;73:928–937. STUDY TYPE: Double-blind, placebo-controlled, randomized clinical trial Atypical antipsychotics are commonly used to reduce irritability and agitation in children with autism spectrum disorder (ASD). Although effective, these medications lead to weight gain and

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Research Update

Efficacy of Quetiapine in PTSD

Topics: Psychopharmacology Tips | PTSD | Research Update

Review of: Villarreal G, Hamner MB, Cañive JM, et al. Efficacy of quetiapine monotherapy in posttraumatic stress disorder: a randomized, placebo-controlled trial. JAMA Psychiatry 2016:ahead of publication. Study Type: Placebo-controlled, double-blinded clinical trial Post-traumatic stress disorder (PTSD) is arguably one of the most difficult psy

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Research Update

Whole-Body Hyperthermia for Depression: Effective or Too Early to Tell?

Topics: Depressive Disorder | Research Update

Review of: Janssen CW, Lowry CA, Mehl MR, et al. Whole-body hyperthermia for the treatment of major depressive disorder: a randomized clinical trial. JAMA Psychiatry 2016;73(8):789-795:ahead of print. Study type: Randomized double-blind sham-controlled trial Saunas and hot tubs are pleasant and “therapeutic” for most of us, so it may be no sur

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Research Update

Treating Complicated Grief: Grief-Focused Psychotherapy Is More Effective Than Citalopram

Topics: Depressive Disorder | DSM | Psychopharmacology Tips | Research Update

Review of: Shear M et al, JAMA Psychiatry, 2016;73:685–694; Study type: Randomized placebo-controlled trial Complicated grief (CG) is a relatively common response in those who have suffered the loss of a loved one. In DSM-5, it is listed in the section on conditions for further study, and it is called “persistent complex bereavement disorder.”

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Research Update

N-acetylcysteine Shows Promise for Skin-Picking Disorder

Topics: OCD | Research Update

Subject: (Grant J et al, JAMA Psychiatry, 2016;73:490–496) Short Description: Excoriation, or what’s often referred to as skin-picking disorder (SPD), is a distressing and disfiguring behavior that affects up to 5% of people, occurring more commonly in women. Various lines of evidence imply that this compulsive behavior may be related to reduce

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Research Update

Buprenorphine for Suicidality? Maybe

Topics: Addiction | Depressive Disorder | Research Update

Subject: (Yovell Y et al, Am J Psychiatry 2016;173:491–498) Short Description: When patients become severely suicidal, we have few good treatment options. These include close monitoring (often in a locked unit), intensive psychotherapy, antidepressants (which, while effective, take weeks to work), a variety of medications to treat symptoms such a

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Research Update

Citalopram Safety Warning Has Serious Consequences for VA Patients

Topics: Depression | Research Update

Subject: (Rector T et al, Am J Psychiatry, 2016; ahead of publication) Short Description: In the summer of 2011, the Food and Drug Administration (FDA) reported that post-marketing surveillance showed that patients taking greater than 40 mg/day of citalopram were at greater risk of QT prolongation. The agency advised doctors not to prescribe doses

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Research Update

Ongoing ECT Does Not Equal Ongoing Cognitive Problems

Topics: Brain Devices | Research Update

Subject: (Kirov G et al, BJ Psych 2016;208:266–270) Short Description: Electroconvulsive therapy (ECT) is well known to cause short-term amnesia and disorientation around the time of treatment. However, for most of our patients, these cognitive side effects improve and disappear fairly quickly, usually within a few days. We have less informat

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Research Update

Second-Generation Antipsychotics Do Not Raise Risk of Major Malformations

Topics: Antipsychotics | Psychopharmacology Tips | Research Update

Subject: (Cohen L et al, JAMA Psychiatry 2016;173:263–270) Short Description: Second-generation antipsychotics (SGA) are used for a variety of psychiatric conditions, but even though they’ve been around for 20 years, we know little about what impact they have on the developing fetus. These medications are widely considered to be relatively safe

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Research Update

Does Light Therapy Work for Non-Seasonal Depression?

Topics: Depressive Disorder | Research Update | Seasonal Affective Disorder

(Lam R et al, JAMA Psychiatry 2016;73(1):56-63) Many studies have shown that light therapy works for seasonal affective disorder, but does it work for non-seasonal major depression? That’s less clear. Systematic reviews have yielded inconclusive results, in part because prior studies have had methodological weaknesses. A new study with a robust des

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