Clinical Update

Medication Management of Antipsychotic-Induced Weight Gain in Children and Teens

Topics: body mass index BMI | GLP-1 Agonists | Metformin | Second Generation Antipsychotics (SGAs) | Topiramate | Weight gain

Of approximately one million US children and adolescents, roughly 1% are prescribed second-generation antipsychotics (SGAs). These medications routinely breach the FDA’s level of concern of >7% body weight gain. The worst offenders are olanzapine, quetiapine, and risperidone; lurasidone and ziprasidone are of less concern (Maayan L and Correll CU,

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Research Update

Topiramate Improves Weight in Schizophrenia in South Asians

Topics: Metabolic syndrome | Schizophrenia | Special populations | Topiramate | Weight gain

REVIEW OF: Chandradasa M et al, Asian J Psychiatr 2022;68:102963 STUDY TYPE: Randomized placebo-controlled trial People with schizophrenia have higher rates of cardiometabolic mortality. There is meta-analytic evidence that adjunctive topiramate reduces weight and improves psychiatric symptoms in schizophrenia. However, there are few studies of th

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Clinical Update

Battle of the Bulge: Obesity and Antipsychotic-Induced Weight Gain

Topics: Aripiprazole | Benzphetamine | Bupropion | Diabetes | Diethylpropion | Exercise | Insulin resistance | Liraglutide | Metabolic syndrome | Metformin | Naltrexone | olanzapine | Phendimetrazine | Phentermine | Samidorphan | Semaglutide | Side Effects | Topiramate | Waist circumference | Weight gain | Ziprasidone

Many psychiatric medications cause weight gain, including mood stabilizers, antidepressants, and especially antipsychotics. Most weight gain secondary to antipsychotic use occurs in the first 6 months of therapy, so it’s important to monitor weight closely and intervene early in a patient’s treatment. We counsel patients at every visit about healthy

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Expert Q&A

Weight Gain and Metabolic Side Effects

Topics: Aripiprazole | Clozapine | Diabetes | Exercise | Insulin resistance | Liraglutide | Metabolic syndrome | Metformin | olanzapine | Quetiapine | Risperidione | Samidorphan | Side Effects | Topiramate | Waist circumference | Weight gain | Ziprasidone

CHPR: Dr. Marder, can you please tell us about your work? Dr. Marder: Sure. My work has focused on pharmacologic and nonpharmacologic approaches to improving the outcomes of serious mental illnesses, particularly schizophrenia. I’m very interested in ways to combine psychosocial interventions with pharmacological approaches and to reduce adverse side

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