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Pristiq vs. Effexor

After many years of trying, Wyeth finally received FDA approval for its new antidepressant, Pristiq (desvenlafaxine). Don’t get too excited, though – Pristiq is simply the active metabolite of Effexor and it’s unclear whether it adds anything of value to our current quiver of antidepressants. Read More

Serious But Rare Antidepressant Side Effects

We typically warn our patients about common side effects, such as headache, GI distress and sexual dysfunction when we start SSRIs. Here are some of the side effects that we don’t necessarily talk to patients about, but should be able to recognize and discuss in particular contexts. Read More

Apparent effectiveness of antidepressants is inflated by publication bias

A former FDA reviewer and his colleagues obtained all FDA data on studies of 12 antidepressants approved between 1987 and 2004. They then scoured the journals to figure which of these studies had been published. They found that of the 74 FDA-registered trials of antidepressants, 23 (31%) had never been published. Read More

Researchers used the Freedom of Information Act to retrieve all clinical trials data from the FDA on four different antidepressants: fluoxetine, venlafaxine, nefazodone, and paroxetine. Read More

Dr. Jeste, I know that you were responsible for some of the original research demonstrating that tardive dyskinesia is a possible side effect of antipsychotics. Why were you interested in the topic? Read More

Psychiatry Practice Boosters, Fourth Edition (2023)
Teaches you the key points of 63 of the most clinically relevant studies in psychiatry.
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General Psychiatry
Using SAMe In Clinical Practice with Garrett Rossi, MD
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General Psychiatry
Throwback Thursday: Brief Therapy for ADHD
You started a stimulant medication for a young woman with ADHD. When she returns her symptoms are 70% better, but what can we do about the rest? Today a conversation with...
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