Prior estimates put antidepressant discontinuation symptom rates as high as 56%. A rigorous meta-analysis of nearly 21,000 patients arrives at a very different number—and it changes how clinicians should counsel patients before tapering.

After two failed antidepressants, remission odds drop below 15%. Is there a better next step than another medication trial? A Dutch RCT pits rTMS head-to-head against pharmacologic switching in treatment-resistant depression.

Valproic acid remains one of psychiatry's most teratogenic drugs. Have years of FDA warnings changed contraceptive and prescribing patterns among women of childbearing age? A large cohort study offers a sobering answer.

Telepsychiatry has become a standard part of emergency and inpatient hospital care, driven by workforce shortages, after-hours coverage needs, and lasting changes from the COVID-19 pandemic.

IV ketamine's rapid antidepressant and anti-suicidal effects make it well suited to the inpatient timeline, where the 6–8-week lag of standard antidepressants is often untenable.

Liver function tests (LFTs) are critical in psychiatry because the liver metabolizes most psychotropic medications, and because heavy alcohol or substance use may impair hepatic function.

Although DSM-5-TR cautions against diagnosing catatonia and delirium at the same time, real-world patients do not always fit neatly into one category. A prospective quality-improvement study of more than 700 medical inpatients found substantial overlap between the two syndromes, with implications for screening and treatment.