Alcohol use disorder (AUD) is notoriously difficult to treat, with pharmacological options often underutilized or only modestly effective. But what if a medication already used for diabetes and obesity could help?

Topiramate matches naltrexone for AUD—and adds perks for patients with obesity, migraines, or binge eating.

Despite its high prevalence, morbidity, and mortality, our treatment options for alcohol use disorder are limited. Severe alcohol use disorder can be especially challenging to treat. Here, researchers demonstrate the efficacy and feasibility of a novel treatment option: deep brain stimulation.