Simvastatin as Adjunctive Therapy for Irritability in Autism
The Carlat Child Psychiatry Report, Volume 9, Number 5, July 2018
Thomas Jordan, MD
Dr. Jordan has disclosed that he has no relevant financial or other interests in any commercial companies pertaining to this educational activity.
Disorders of lipid metabolism—specifically inefficient metabolism of lipids—have been implicated as part of the metabolic complexity in children with autism spectrum disorder. Research points to the neuroprotective effects of simvastatin over other statins, due to its greater ability to cross the blood-brain barrier. But does that neuroprotection translate to differences in behavior?