Predicting Antidepressant Response
The Carlat Psychiatry Report, Volume 10, Number 5, May 2012
Andrew Leuchter, MD
Professor of psychiatry, David Geffen School of Medicine, Director, Laboratory of Brain, Behavior, and Pharmacology, Semel Institute for Neuroscience and Human Behavior, University of California, Los Angeles
Dr. Leuchter has disclosed that he has been a paid consultant to NeoSync Inc. on the NeoSync EEG Synchronized TMS device (NEST). Dr. Balt has reviewed this article and found no evidence of bias in this educational activity.
I don’t think that there is any effective, proven way to predict medication response. I have been involved in research on biomarkers—we call them “response endophenotypes”—such as EEG, where we look at the physiologic response of the brain to a new drug and try to determine whether the drug will work for that patient.