Topiramate (Topamax) is somewhat effective for alcohol dependence, but heavy on side effects
The Carlat Psychiatry Report, Volume 5, Number 11, November 2007
Topics: Substance Abuse
Rebecca W. Brendel, MD, JD
Medications only work modestly for the treatment of alcohol dependence. In TCPR’s last issue on substance abuse (June 2006) we reviewed the evidence on disulfiram (Antabuse), naltrexone, and acamprosate, and concluded that naltrexone works modestly, acamprosate works less well, and Antabuse has little high quality data but probably works modestly for highly motivated patients.
Rebecca W. Brendel, MD
Assistant Director, Forensic Fellowship Program, Law & Psychiatry Service, Massachusetts General Hospital Instructor in Psychiatry, Harvard Medical School
Dr. Brendel has disclosed that she has no significant relationships with or financial interests in any commercial companies pertaining to this educational activity.