• Home
  • Store
    • Newsletter Subscriptions
    • Multimedia Subscriptions
    • Books
    • eBooks
    • ABPN SA Courses
  • CME Center
  • Multimedia
    • Podcast
    • Webinars
    • Blog
  • Newsletters
    • General Psychiatry
    • Child Psychiatry
    • Addiction Treatment
    • Hospital Psychiatry
    • Geriatric Psychiatry
  • Log In
  • Register
  • Welcome
  • Sign Out
  • Subscribe
Home » The Birth of "Panic Disorder"

The Birth of "Panic Disorder"

March 1, 2006
From The Carlat Psychiatry Report
Issue Links: Learning Objectives | Editorial Information
In the dark old days of American Psychiatry, most patients were diagnosed with schizophrenia and prescribed Thorazine (chlorpromazine) or its equivalent. One of the true pioneers of rational medication treatment is Donald Klein of Columbia University, who in 1962 was a psychiatrist practicing at Hillside Hospital in New York. He and his colleague Max Fink published an early study in Archives of General Psychiatry in which they documented the responses of a variety of patients to imipramine vs. chlorpromazine. One patient in particular (diagnosed as schizophrenic) suffered an "atypical" syndrome of paroxysmal episodes of fear and agitation that would last for several minutes and then subside. He did not respond to Thorazine, but these episodes diminished on robust doses of imipramine. Klein later labeled these "paroxysmal" episodes "panic attacks," but it was not until 1980 that the concept of panic disorder gained acceptance in American psychiatry. It was in that year that David Sheehan and colleagues published a seminal article on "Endogenous Anxiety". Soon thereafter, Upjohn introduced Xanax (alprazolam), and panic disorder was rapidly transformed from an unknown disorder to one of the most commonly treated conditions in psychiatry.

Source: Sheehan DV, Ballenger J, and Jacobsen G: Treatment of endogenous anxiety with phobic, hysterical, and hypochondriacal symptoms. Archives of General Psychiatry. 1980;37:51-57.
General Psychiatry
    www.thecarlatreport.com
    Issue Date: March 1, 2006
    SUBSCRIBE NOW
    Table Of Contents
    Medications for Panic Disorder: An Update
    Benzodiazepines are Bad. Or Are They?
    The Role of GABA in Anxiety
    The Birth of "Panic Disorder"
    Featured Book
    • MFB6eCover.jpg

      Medication Fact Book for Psychiatric Practice, Sixth Edition (2022)

      Guidance, clinical pearls, and bottom-line assessments covering the medications you use in your...
      READ MORE
    Featured Video
    • therapist_canstockphoto9201097.jpg
      General Psychiatry

      Using SAMe In Clinical Practice with Garrett Rossi, MD

      Read More
    Featured Podcast
    • canstockphoto22709844.jpg
      General Psychiatry

      Psychopharm Commandment #10: Don’t Fear these Meds

      Surprising health benefits of our riskiest meds: Lithium, quetiapine, and clozapine.

      Listen now
    Recommended
    • Approaches to Autism Intervention

      January 31, 2022
      canstockphoto2240982_child-bubbles_thumb.jpg
    • Currently Available Cannabis Products

      September 1, 2022
    • Interpreting Assessment Discrepancies from Multiple Sources

      October 17, 2022
      ChildAssessment.png
    • Approaches to Autism Intervention

      January 31, 2022
      canstockphoto2240982_child-bubbles_thumb.jpg
    • Currently Available Cannabis Products

      September 1, 2022
    • Interpreting Assessment Discrepancies from Multiple Sources

      October 17, 2022
      ChildAssessment.png
    • Approaches to Autism Intervention

      January 31, 2022
      canstockphoto2240982_child-bubbles_thumb.jpg
    • Currently Available Cannabis Products

      September 1, 2022
    • Interpreting Assessment Discrepancies from Multiple Sources

      October 17, 2022
      ChildAssessment.png

    About

    • About Us
    • CME Center
    • FAQ
    • Contact Us

    Shop Online

    • Newsletters
    • Multimedia Subscriptions
    • Books
    • eBooks
    • ABPN Self-Assessment Courses

    Newsletters

    • The Carlat Psychiatry Report
    • The Carlat Child Psychiatry Report
    • The Carlat Addiction Treatment Report
    • The Carlat Hospital Psychiatry Report
    • The Carlat Geriatric Psychiatry Report

    Contact

    info@thecarlatreport.com

    866-348-9279

    PO Box 626, Newburyport MA 01950

    Follow Us

    Please see our Terms and Conditions, Privacy Policy, Subscription Agreement, Use of Cookies, and Hardware/Software Requirements to view our website.

    © 2023 Carlat Publishing, LLC and Affiliates, All Rights Reserved.