• Home
  • Store
    • Newsletter Subscriptions
    • Multimedia Subscriptions
    • Books
    • eBooks
    • ABPN SA Courses
  • CME Center
  • Multimedia
    • Podcast
    • Webinars
    • Blog
  • Newsletters
    • General Psychiatry
    • Child Psychiatry
    • Addiction Treatment
    • Hospital Psychiatry
    • Geriatric Psychiatry
    • Psychotherapy and Social Work
  • Log In
  • Register
  • Welcome
  • Sign Out
  • Subscribe
Home » Provigil for the Masses?

Provigil for the Masses?

April 1, 2007
From The Carlat Psychiatry Report
Issue Links: Learning Objectives | Editorial Information | PDF of Issue
Louann Brizendine, MD

Provigil (modafinil) is FDA approved for excessive sleepiness due to various causes. An ADHD indication was rejected because of its possible association with a single case of Stevens-Johnson syndrome. Nonetheless, Provigil enjoys wide use for off-label indications, including medica- tion-associated fatigue, augmentation of antidepressants, and as a pick-me-up for the frazzled and exhausted 21st-century human. A group of researchers at Vanderbilt University has recently reported on the effects of Provigil on 12 healthy male volunteers aged 30 to 44. Patients were randomized to either three days of Provigil 400 mg/day or placebo. Provigil made subjects feel more energized, alert, and quick-witted than did placebo, but it also produced more anxiety and tension (Taneja I et al., J Clin Psychopharm Feb 2007;27(1):76-78). In a separate report on the same subjects, Provigil was associated with a nine-beat increase in heart rate, a seven-point increase in systolic blood pressure, and a five-point increase in dias- tolic blood pressure (Taneja I et al., Hypertension 2005;45:612).

TCPR’s Take: Provigil energizes but causes autonomic activation when given to non-fatigued volunteers. This could be hazardous for people with cardiac disease. Let patients know that there are hazards associated with sharing their Provigil with family or friends who seek a quick boost. Caffeine is probably safer.

General Psychiatry
    www.thecarlatreport.com
    Issue Date: April 1, 2007
    SUBSCRIBE NOW
    Table Of Contents
    Vyvanse Approved for ADHD
    Psychotropics and Pregnancy: A 2007 Update
    Prescribing Medications during Pregnancy and Breastfeeding
    Treating Depression in Perimenopause
    Provigil for the Masses?
    Does “California Rocket Fuel” Work?
    What Are the Stages of Grief?
    DOWNLOAD NOW
    Featured Book
    • PB4e_Cover2.png

      Psychiatry Practice Boosters, Fourth Edition (2023)

      Teaches you the key points of 63 of the most clinically relevant studies in psychiatry.
      READ MORE
    Featured Video
    • therapist_canstockphoto9201097.jpg
      General Psychiatry

      Using SAMe In Clinical Practice with Garrett Rossi, MD

      Read More
    Featured Podcast
    • canstockphoto6759394.jpg
      General Psychiatry

      Throwback Thursday: Brief Therapy for ADHD

      You started a stimulant medication for a young woman with ADHD. When she returns her symptoms are 70% better, but what can we do about the rest? Today a conversation with...

      Listen now
    Recommended
    • Approaches to Autism Intervention

      January 31, 2022
      canstockphoto2240982_child-bubbles_thumb.jpg
    • Currently Available Cannabis Products

      September 1, 2022
    • Interpreting Assessment Discrepancies from Multiple Sources

      October 17, 2022
      ChildAssessment.png
    • Approaches to Autism Intervention

      January 31, 2022
      canstockphoto2240982_child-bubbles_thumb.jpg
    • Currently Available Cannabis Products

      September 1, 2022
    • Interpreting Assessment Discrepancies from Multiple Sources

      October 17, 2022
      ChildAssessment.png
    • Approaches to Autism Intervention

      January 31, 2022
      canstockphoto2240982_child-bubbles_thumb.jpg
    • Currently Available Cannabis Products

      September 1, 2022
    • Interpreting Assessment Discrepancies from Multiple Sources

      October 17, 2022
      ChildAssessment.png

    About

    • About Us
    • CME Center
    • FAQ
    • Contact Us

    Shop Online

    • Newsletters
    • Multimedia Subscriptions
    • Books
    • eBooks
    • ABPN Self-Assessment Courses

    Newsletters

    • The Carlat Psychiatry Report
    • The Carlat Child Psychiatry Report
    • The Carlat Addiction Treatment Report
    • The Carlat Hospital Psychiatry Report
    • The Carlat Geriatric Psychiatry Report
    • The Carlat Psychotherapy Report

    Contact

    info@thecarlatreport.com

    866-348-9279

    PO Box 626, Newburyport MA 01950

    Follow Us

    Please see our Terms and Conditions, Privacy Policy, Subscription Agreement, Use of Cookies, and Hardware/Software Requirements to view our website.

    © 2023 Carlat Publishing, LLC and Affiliates, All Rights Reserved.