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Home » Pediatric bipolar vs. severe mood dysregulation: New evidence

Pediatric bipolar vs. severe mood dysregulation: New evidence

September 1, 2007
From The Carlat Psychiatry Report
Issue Links: Learning Objectives | Editorial Information | PDF of Issue
Ronald Pies, MD

The controversy over pediatric bipolar disorder has heated up over the past year. A recent study offers evidence for those favoring “narrow” criteria for the pedi- atric bipolar diagnosis. Researchers inter- viewed children brought into an NIMH treatment center, and classified 33 as hav- ing “narrow phenotype bipolar disorder” (meaning that they met standard DSM-4 criteria, including grandiose manic episodes) vs. 30 as having “severe mood dysregulation” (primary mood irritable, angry or sad, plus hyperarousal symptoms, plus frequent temper tantrums). Next, dif- ferent researchers interviewed parents of these children to see whether children with narrowly defined bipolar were more likely to have bipolar parents than chil- dren with severe mood dysregualtion. These interviewers were blind to the child’s diagnosis. The results? 33.3 % of parents of narrow bipolar kids were diag- nosed with bipolar disorder, vs. only 2.7% of parents of mood dysregulation kids.

TCPR’s Take: Since kids with narrow bipolar are about 10 times more likely to have a bipolar parent than kids with severe mood dysregulation, the implication is that severe mood dysregulation is less likely to be “true” bipolar disorder. However, it’s not clear how much this matters, since mood stabilizing medications are often

General Psychiatry
KEYWORDS bipolar_disorder child-psychiatry
    www.thecarlatreport.com
    Issue Date: September 1, 2007
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    Table Of Contents
    Combining Meds for Depression: The State of The Art
    Dosing Psychotropics: How High Can We Go?
    Managing Side Effects of Psychotropics
    Pediatric bipolar vs. severe mood dysregulation: New evidence
    Provigil better than placebo for bipolar depression
    First controlled trial of sibutramine vs. topiramate in bipolar disorder
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