When I think of a child with autism, I want to discover who he is—not just his diagnosis, but how he relates, feels, functions, and learns in the context of family, culture, environment, and education.

Disorders of lipid metabolism—specifically inefficient metabolism of lipids—have been implicated as part of the metabolic complexity in children with autism spectrum disorder. Research points to the neuroprotective effects of simvastatin over other statins, due to its greater ability to cross the blood-brain barrier. But does that neuroprotection translate to differences in behavior?

Why do children with autism spectrum disorder (ASD) have tantrums? One theory is that these tantrums are due in part to children’s frustration with not being able to express themselves. This theory has led to a treatment approach called “mand training.”

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Why would an antibiotic be helpful in psychiatry? Minocycline crosses the blood-brain barrier and may have neuroprotective effects. A recent study tested whether minocycline might be useful as an adjunct to risperidone for ASD.

Clinicians used to say, “Oh, autism is very clear. It’s the one true disorder in child psychiatry.” Now we realize that there’s a spectrum, which makes some sense, especially from a broad evolutionary perspective: If these changes were totally maladaptive, they presumably would have been lost over time; instead, they’ve persisted. That suggests that, for some people, some other combinations of these genes must be somewhat or even quite adaptive.

The post-test for this issue is available for one year after the publication date to subscribers only. By successfully completing the test you will be awarded a certificate for 2 CME credits.

Atypical antipsychotics are commonly used to reduce irritability and agitation in children with autism spectrum disorder (ASD). Although effective, these medications lead to weight gain and other metabolic problems. Strategies like tailored diet plans and exercise can help, but they are often not enough. If not interrupted early, for many, continued weight gain will lead to diabetes, hypertension, and heart disease later in life.

Atypical antipsychotics are commonly used to reduce irritability and agitation in children with autism spectrum disorder (ASD). Although effective, these medications lead to weight gain and other metabolic problems. Strategies like tailored diet plans and exercise can help, but they are often not enough. If not interrupted early, for many, continued weight gain will lead to diabetes, hypertension, and heart disease later in life.