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Placebo response rates in antidepressant trials tend to run high, making it difficult to know whether an active medication has truly beneficial effect. This research update unpacks possible reasons for this phenomenon that give you insight into how to treat your patients using a rational multimodal approach.

Are stimulant medication likely to exacerbate anxiety in ADHD kids? It’s reasonable concern, especially since mood symptoms can be worse with withdrawal and heart rate goes up in some kids on stimulants. This study gives nuanced insight into the degree to which stimulants impact anxiety in ADHD kids, for better and worse.

Parents suffer significant stress, doing their best to support and care for their ADHD kids. Does that stress dissipate at all when the ADHD is alleviated? This controlled trial looked at stress levels of parents whose kids were taking delayed release/extended release methylphenidate versus those taking placebo. 

With so many medications and supplements to try for ADHD, what combinations are effective? This research update looks at a study that tested whether adding Co-Q10 to atomoxetine treatment might improve outcomes in ADHD. Our analysis of this approach is a guide to other combination approaches to ADHD.