We all learn that patients with alcohol use disorder should receive thiamine supplementation. But why, and how should it be given? We discuss the pathophysiology that underlies thiamine deficiency in alcohol use disorder and why it is so important. We then go over the latest thiamine supplementation guidelines.

Various formulations of buprenorphine abound, and a new long-acting injectable form (Sublocade) is one of the latest arrivals. But does it actually work? Here, we review the pharmacology behind it, go over efficacy data, and provide guidance on how to decide when to consider long-acting injectable buprenorphine for your patients.