A massive meta-analysis of over one million participants provides the most comprehensive real-world comparison to date of methadone versus buprenorphine for opioid use disorder. While both medications are effective, methadone shows superior treatment retention at 3, 6, and 12 months, though the medications are largely comparable in other outcomes.

The first randomized controlled trial testing varenicline for e-cigarette cessation shows encouraging results. With 45% of participants achieving 7-day abstinence at week eight compared to 30% on placebo, this study provides preliminary evidence that varenicline may be effective for helping patients quit vaping, expanding its utility beyond traditional tobacco cessation.

A new digital tool helps clinicians compare psychiatric medications based on side effect profiles—streamlining complex decisions with data from dozens of major studies and treatment guidelines.

Researchers compares treatments for antipsychotic-induced akathisia, highlighting options that may offer relief with fewer side effects.

It’s difficult to find options when clozapine does not work.

We know that stimulant medications for ADHD can reduce chronic health conditions and extend healthy years for patients. But are there cardiovascular risks from these or non-stimulant medications used for ADHD? In this research update, we review a study that helps clarify the risks of long term use in youth and adults.