SAINT TMS is now available. We take a closer look at its record-breaking effect size.

Owen Muir, MD, believes TMS ought to come before antidepressants for many teens with depression, but does the FDA agree with him?

This page has links and instructions for downloading your PDF and eBook copies of Difficult To Treat Depression: A Carlat Guide (2026) and completing the 12 CME Post-Test.

Do TMS and psychotherapy share a common mechanism? We talk with Owen Muir about how to engage patients with this magnetic therapy.

When bipolar disorder and substance use disorders co-occur patients can be difficult to diagnose and treat, particularly because they often present with mixed states rather than classic mood episodes. This article reviews evidence-based treatment approaches for specific substance combinations, including valproate for alcohol use, citicoline for stimulant use, and considerations for managing this complex dual diagnosis.

Second-generation antipsychotics have cut the risk of tardive dyskinesia (TD) in half—from 7% to 3% per year—but it is still a problem.

Lithium, pramipexole, bupropion, carbamazepine, valproate, and trazodone. Meds that require special skill to start: 

Meds that require special skill to start: Clozapine and lamotrigine.

Ziprasidone and quetiapine. One goes better fast, one slow. Also the mystery of ghost pills, and a research update on pramipexole.