Asenapine’s unique advantage is its availability in both sublingual and transdermal patch formulations, making it useful for patients who cannot or prefer not to swallow pills.

Nefazodone was once popular due to its low rate of sexual side effects, but its use has dramatically declined because of rare yet serious hepatic toxicity.

Pregabalin is structurally related to gabapentin and is likely more effective for psychiatric disorders, especially generalized anxiety disorder (GAD) and social anxiety disorder. 

Atomoxetine is a nonstimulant attention-deficit/hyperactivity disorder (ADHD) treatment that carries no abuse potential, causes less insomnia and anxiety, and is unlikely to worsen tics.

St. John’s wort may be considered for short-term treatment of mild to moderate depression, especially in patients seeking natural options. However, its extensive drug interaction profile limits broader clinical use.

Vilazodone is essentially an SSRI with added buspirone-like 5-HT1A partial agonist effects.

TCAs are less commonly used today due to side effects and overdose risk but remain a valid option for patients who haven’t responded to other antidepressants.

Trazodone is most often prescribed at low doses (25–50 mg) as a sleep aid.