antipsychotics - Page 1 | CARLAT PUBLISHING

RESEARCH UPDATE

Mirtazapine and B6 Outperform Propranolol for Akathisia

June 1, 2025

Steven Hamilton, PhD, MD.

Dr. Hamilton has no financial relationships with companies related to this material.

Researchers compares treatments for antipsychotic-induced akathisia, highlighting options that may offer relief with fewer side effects.

The First Antipsychotic

June 1, 2025

The first antipsychotic medication was discovered by a French naval surgeon named Henri Laborit. Dr. Laborit had little interest in psychiatry, but was avidly seeking a way to better treat wounded soldiers who were in shock.

Expert Q&A

Akathisia: Manifestations and Treatment

January 1, 2025

Michael Poyurovsky, MD

Michael Poyurovsky, MD

Associate professor, Rappaport Faculty of Medicine, Technion Israel Institute of Technology, Haifa, Israel.

Dr. Poyurovsky has no financial relationships with companies related to this material.

Dr. Poyurovsky offers practical guidance for identifying and treating akathisia, a movement disorder marked by inner restlessness. He highlights the importance of psychoeducation, gradual dose adjustments, and the use of propranolol or low-dose mirtazapine for relief. He underscores the importance of distinguishing akathisia from other conditions, like psychotic agitation, to avoid unnecessary increases in antipsychotic doses.

Research Update

Strategies to Reduce Antipsychotic-Induced Hyperprolactinemia

January 1, 2025

Sarah Azarchi, MD

Sarah Azarchi, MD. Dr. Azarchi has no financial relationships with companies related to this material.

Five strategies to reduce prolactin on antipsychotics tested in this meta-analysis

Research Update

Esketamine vs Quetiapine in Treatment-Resistant Depression

November 1, 2024

Ivy Song, MD

Ivy Song, MD. Dr. Song has no financial relationships with companies related to this material.

Esketamine outperforms quetiapine in TRD remission rates, but the clinical significance of this difference remains uncertain.

Research Update

How Long to Wait Before Changing Antipsychotics in Schizophrenia?

October 1, 2024

Lara Tang, MD

Lara Tang, MD. Dr. Tang has no financial relationships with companies related to this material.

How long should you wait before making changes after initiating an antipsychotic? The current study tested if early efficacy on an antipsychotic predicts subsequent efficacy, and its findings indicate benefits may be observed as quickly as two weeks.

Research Update

Antipsychotic Dosing: Differences Between Bipolar Mania and Schizophrenia

August 1, 2024

Kate J. Travis, MD

Kate Travis, MD. Dr. Travis has no financial relationships with companies related to this material.

Conventional wisdom suggests that antipsychotics need similar doses for mania and schizophrenia. This analysis clarifies the exceptions.

Expert Q&A

Treatment Challenges in Atypical Parkinsonism

July 1, 2024

Alice Flaherty, MD, PhD

Alice Flaherty, MD, PhD.

Neurologist, Massachusetts General Hospital; associate professor of neurology and psychiatry, Harvard Medical School, Cambridge, MA.

Dr. Flaherty has no financial relationships with companies related to this material.

Patients with atypical parkinsonism are less responsive to levodopa, and psychiatric medications can exacerbate motor symptoms. Dr. Flaherty advises how to choose the right treatment in patients with parkinsonism accompanied by psychosis, apathy, anxiety, and depression.

Research Update

Antipsychotic Polypharmacy: Maybe Not So Risky After All?

July 1, 2024

Sébastien Hardy, PharmD, BCPS

Sébastien Hardy, MD. Dr. Hardy has no financial relationships with companies related to this material.

The findings of this large study offer some reassurance about the safety and efficacy of antipsychotic polypharmacy, despite general treatment guidelines cautioning against it.

Clinical Update

Don’t Delay: Interventions in Early Psychosis

July 1, 2024

Brian Holoyda, MD, MPH, MBA

Brian Holoyda, MD. Chief Psychiatrist, Contra Costa County Detention Health Services, Martinez, CA. Dr. Holoyda has no financial relationships with companies related to this material.

We highlight the profound difference early intervention makes in the trajectory of psychotic disorders, reducing symptom severity, suicide risk, and functional impairment.