A massive meta-analysis of over one million participants provides the most comprehensive real-world comparison to date of methadone versus buprenorphine for opioid use disorder. While both medications are effective, methadone shows superior treatment retention at 3, 6, and 12 months, though the medications are largely comparable in other outcomes.

The first randomized controlled trial testing varenicline for e-cigarette cessation shows encouraging results. With 45% of participants achieving 7-day abstinence at week eight compared to 30% on placebo, this study provides preliminary evidence that varenicline may be effective for helping patients quit vaping, expanding its utility beyond traditional tobacco cessation.

Tobacco smoking and major depression are highly comorbid, and depressed patients usually have a tougher time quitting than their non-depressed counterparts. In this research study, investigators compared the efficacy of anti-smoking medications in those with depression. The results may surprise you.

Evidence for the use of e-cigarettes as smoking cessation agents continues to evolve. In this observational study, researchers find that e-cigarettes modestly increase the risk of relapse to smoking in patients who have managed to quit.