The Memantine Story
No, contrary to all appearances, memantine is not yet FDA approved for dementia. A spate of Forest-funded journal supplements and CME-Inc courses are apparently aimed at whetting our appetites, but they are about 6 months early. Memantine is an NMDA antagonist, and tries to prevent too much glutamate from pounding neurons already surrounded by beta-amyloid glue. The studies so far show modest efficacy, no better than the AchEIs, (and no better for severe dementia than AChEIs.) One study finds it to be an effective adjunct to Aricept, and this plus its good side effect profile will likely make it popular.
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