The fall season, when many kids experience sadness related to changes in daylight and increased demands of school, is the right time to think about depression. And in this issue, we present a long-awaited piece on school refusal. But the news cycle is prominent, and I am adding our voice on acetaminophen, vaccines, and autism. The largest study to date on in utero acetaminophen exposure included over 185,000 kids and found no increased risk for autism (Alqvist VH et al, JAMA 2024;331(14):1205–1214). Vaccine studies have also failed to show a credible link with autism. I worry about the relative toxicity of acetaminophen, which is higher than people have realized (Harris G. No More Tears. New York, NY: Random House; 2025). Yet, I also worry about broad recommendations to avoid it since high fevers in childhood can create their own problems, such as increased risk for seizures and potentially for ADHD. At CCPR, we are careful with medications but use them when warranted. And on leucovorin for autism? It’s pretty benign but we need more research on efficacy. Carlat Publishing is planning to interview Dr Frye, a key figure in leucovorin research. Stay tuned!