First thing's first. What's the deal with all the confusing names for Depakote? The basic, irreducible molecule here is valproic acid, also known as valproate, and the brand name of this is "Depakene", not Depakote.

Dr. Ghaemi, I thought we could discuss this rather controversial issue of whether antidepressants (ADs) should be prescribed in bipolar disorder, particularly in light of the recent article published in the American Journal of Psychiatry by Altshuler et. al. (1).

The discovery of the therapeutic effects of lithium is one of the most fabulous examples of serendipity in all of science. In 1949, John Cade was a 37 year old superintendent of a psychiatric hospital in the Australian outback.

Dr. Carol Edelstein is a psychiatrist in private practice in Los Angeles, California, and has a particular interest in eating disorders. She describes a case below that falls in that vague hinterland between cyclothymia and bipolar disorder, type II.

We apologize in advance. But it was inevitable that TCR would eventually have to tackle what may be the most boring topic in all of psychiatry, if not medicine in general: Drug-drug interactions.

Drug interactions are enormously complicated. In tried and true TCR fashion, I have tried to make this topic easier to stomach. Nonetheless, you can skip this article if you make a decision to avoid prescribing the following medications ...

When it comes to Lithium, you can (thankfully) forget all about the P450 enzymes, because they don't touch this salt. Lithium enters the bloodstream, accomplishes its mysterious mood-stabilizing duties, and then is simply whisked out of the body intact by the kidneys via urine. So with Lithium, it's all about kidneys.

Dr. Sandson, you've just published the definitive casebook on drug interactions (1), and you obviously have thought long and hard about the issue. What do you think psychiatrists really need to know about drug-drug interactions?

The concept of drug-drug interactions in psychiatry surfaced surprisingly recently. In 1988, a small letter was published in the American Journal of Psychiatry by Dr. D. A. Vaughan, a psychiatrist in practice in Wichita, Kansas. Dr. Vaughan described two women he had been treating for depression with tricyclics.

Alan Ringold, M.D., is a psychiatrist in private practice in Palo Alto, California. He is particularly astute when it comes to drug interactions, and he clearly made the right call in the following situation.