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Home » Topics » General Psychiatry

General Psychiatry
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Gender Affirming Care in Exile: Targeting the Leader

May 11, 2026
Chris Aiken, MD and Kellie Newsome, PMHNP

The president of the US branch of WPATH built one of the largest youth gender clinics in the country, then watched it close under political fire. Now she's facing a malpractice lawsuit from a former patient. We examine the unpublished study at the center of the controversy.

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When Social Withdrawal Becomes Invisible Pathology

May 8, 2026
Daniel Carlat, MD

Have you ever heard of hikikomori? Literally: "pulling inward."

First described by Japanese psychiatrist Tamaki Saito in 1998 — and for decades assumed to be a uniquely Japanese problem. 

It isn't.

A 2025 meta-analysis of 19 studies and 58,000+ participants found cases across Europe, North America, and beyond. US estimates put prevalence around 2–3%. Roughly 1 in 40 Americans.




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Clinical Update

Helping Patients Tolerate Anti-Manic Treatments

May 7, 2026
Chris Aiken, MD
From The Carlat Psychiatry Report
Issue Links: Editorial Information | PDF of Issue

Chris Aiken, MD. Editor-in-Chief, The Carlat Psychiatry Report. Assistant Professor, NYU Langone Department of Psychiatry. Practicing psychiatrist, Winston-Salem, NC.

Dr. Aiken has no financial relationships with companies related to this material.

Mania requires rapid treatment, but side effects often undermine adherence. Learn practical strategies to improve tolerability and when to consider off-label or behavioral options.


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Gender Affirming Care in Exile: The Trials

May 4, 2026
Chris Aiken, MD and Kellie Newsome, PMHNP

Medical societies are reversing decades of support for gender-affirming care in youth — but is it the science driving the shift, or the politics? This episode walks through the evidence, from randomized trials to regret rates, and finds a more complicated picture than either side presents.

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Research Update

Prazosin and Cyproheptadine for AUD: A Promising Combination

May 1, 2026
Christine Tran-Boynes, DO
From The Carlat Psychiatry Report
Issue Links: Editorial Information | PDF of Issue

Christine Tran-Boynes, DO. Dr. Tran-Boynes has no financial relationships with companies related to this material.

When standard treatments fall short in alcohol use disorder, could a prazosin–cyproheptadine combination help? A new randomized trial suggests this pairing may significantly reduce high-risk drinking.


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Learning Objectives

Learning Objectives, Borderline Personality Disorder, TCPR, May 2026

May 1, 2026
From The Carlat Psychiatry Report
Issue Links: Editorial Information | PDF of Issue

After reading these articles, you should be able to…



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CME Post-Test, Borderline Personality Disorder, TCPR, May 2026

May 1, 2026
From The Carlat Psychiatry Report
Issue Links: Editorial Information | PDF of Issue

By successfully completing the test you will be awarded a certificate for 1 CME credit.


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Expert Q&A

Diagnosing Borderline Personality

May 1, 2026
Mark Zimmerman, MD
From The Carlat Psychiatry Report
Issue Links: Editorial Information | PDF of Issue

Chief of Ambulatory Psychiatry and Behavioral Health, South County Psychiatry. Former professor of psychiatry and human behavior, Warren Alpert Medical School, Brown University.

Dr. Zimmerman reports he is on the speaker’s bureau of Intra Cellular Therapies and a research consultant with GH Research. This article was reviewed by Dr. Aiken, Editor-in-Chief, who has concluded that there is no evidence of commercial bias in this educational activity.

Dr. Zimmerman explains why BPD is underdiagnosed and how a single high-yield screening question can change your assessment.


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Research Update

Do “Other” Events Trigger Post-Traumatic Stress Disorder?

May 1, 2026
Alex Evans, PharmD, MBA.
From The Carlat Psychiatry Report
Issue Links: Editorial Information | PDF of Issue

Alex Evans, PharmD, MBA. Dr. Evans has no financial relationships with companies related to this material.

What if a patient’s most traumatic experience doesn’t meet DSM-5 criteria? This study explores how other life events can trigger PTSD-level symptoms—challenging how we define trauma.



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Research Update

Treating Antipsychotic-Induced Weight Gain with GLP-1 Agonists

May 1, 2026
Christine Tran-Boynes, DO
From The Carlat Psychiatry Report
Issue Links: Editorial Information | PDF of Issue

Christine Tran-Boynes, DO.

Dr. Tran-Boynes has no financial relationships with companies related to this material.

GLP-1 agonists have transformed obesity care—now emerging research suggests they may also reverse antipsychotic-induced weight gain without worsening psychiatric symptoms.


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Featured Book
  • MFB8e_SpiralCover.png

    Medication Fact Book for Psychiatric Practice, Eighth Edition (2026)

    Updated 2026 prescriber's guide.
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Featured Video
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    General Psychiatry

    KarXT (Cobenfy): The Breakthrough Antipsychotic That Could Change Everything

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    General Psychiatry

    Gender Affirming Care in Exile: The Lawsuits

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