General Psychiatry
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Is It Possible that Antidepressants Really Don’t Work?

May 1, 2012
Michael Posternak, MD
Michael Posternak, MD Psychiatrist in private practice, Boston, MA Dr. Posternak has disclosed that he has no relevant relationships or financial interests in any commercial company related to this educational activity.
A heated debate over how well psychiatric medications actually work has led some authorities in our field to suggest that psychiatry is currently experiencing a “crisis of confidence.”
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Future Developments in Antidepressant Therapy

May 1, 2012
Kelly Gable, PharmD, BCPP and Steve Balt, MD
Kelly Gable, PharmD, BCPP Assistant professor of pharmacy practice, Southern Illinois University, Edwardsville, School of Pharmacy Dr. Gable has disclosed that she has no relevant relationships or financial interests in any commercial companies pertaining to this educational activity. Steve Balt, MD Research fellow, Addiction Pharmacology Research Laboratory, California Pacific Medical Center Dr. Balt discloses that his spouse is employed as a sales representative for Bristol Myers Squibb.
In 2011 in the pages of TCPR, we asked, “What’s new in antidepressant treatment?” The answer was “not much” (TCPR, April 2011). In 2012, unfortunately, the answer isn’t very different.
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EXPERT Q&A

Predicting Antidepressant Response

May 1, 2012
Andrew Leuchter, MD
Andrew Leuchter, MD

Professor of psychiatry, David Geffen School of Medicine, Director, Laboratory of Brain, Behavior, and Pharmacology, Semel Institute for Neuroscience and Human Behavior, University of California, Los Angeles
Dr. Leuchter has disclosed that he has been a paid consultant to NeoSync Inc. on the NeoSync EEG Synchronized TMS device (NEST). Dr. Balt has reviewed this article and found no evidence of bias in this educational activity.

I don’t think that there is any effective, proven way to predict medication response. I have been involved in research on biomarkers—we call them “response endophenotypes”—such as EEG, where we look at the physiologic response of the brain to a new drug and try to determine whether the drug will work for that patient.
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Can a Blood Test Diagnose Depression?

May 1, 2012
Glen Spielmans, PhD
Glen Spielmans, PhD Associate professor of psychology, Metropolitan State University, St. Paul, MN Glen Spielmans, PhD, has disclosed that he has no relevant financial or other interests in any commercial companies pertaining to this educational activity.
Psychiatrists have long wondered whether someday we might have an objective way to diagnose depression, in much the same way an internist orders a blood test or X-ray. A recent article suggests that just such a test might be on the horizon. Is it the real deal?
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Sexual and Gender Diversity: Practice Tips

April 1, 2012
Inge Hansen, PsyD
Inge Hansen, PsyD Psychologist & manager of the Weiland Health Initiative, Stanford University Dr. Hansen has disclosed that she has no relevant relationships or financial interests in any commercial companies pertaining to this educational activity.
Patients who identify themselves within the broad category of LGBTQ (lesbian, gay, bisexual, transgender, and queer or questioning) are an increasingly visible population. Research has consistently shown that LGBTQ-identified individuals suffer higher rates of depression, suicide, anxiety, smoking, substance abuse, and sexually transmitted infections (STIs) than the general population.
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A Primer on Transgender Care

April 1, 2012
Dan Karasic, MD
Dan Karasic, MD Clinical professor of health sciences, Department of Psychiatry, University of California, San Francisco Dr. Karasic has disclosed that he has no relevant relationships or financial interests in any commercial companies pertaining to this educational activity.
Most psychiatrists have not been specifically trained in treating transgender patients. This is a problem, because as society has become more accepting of sexual and gender diversity, more of your patients are likely to divulge to you their transgender identity.
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The Struggles of ‘Coming Out’

April 1, 2012
Loren A. Olson, MD
Loren A. Olson, MD Psychiatrist and author Dr. Olson has disclosed that he receives book royalties from InGroup Press. Dr. Balt has reviewed this article and found no evidence of bias in this educational activity.
Dr. Olson, you are a psychiatrist with a special interest in sexuality, but from a personal perspective, you also wrote a book about your own experience coming out as gay later in life.
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Thyroid Function

April 1, 2012
Glen Spielmans, PhD
Glen Spielmans, PhD Associate professor of psychology, Metropolitan State University, St. Paul, MN Glen Spielmans, PhD, has disclosed that he has no relevant financial or other interests in any commercial companies pertaining to this educational activity.
True thyroid dysfunction can present with symptoms as wide-ranging as depression, mania, psychosis, or poor cognition.
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