Clear, engaging, and practical updates on clinical psychiatry.

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How Buspirone Mixed with Melatonin to Make an Antidepressant

February 22, 2021 | Podcasts

In 2012, psychiatrists at Harvard’s Massachusetts General Hospital discovered a novel antidepressant. It seemed to improve depression and cognition without causing any significant side effects. There was only one problem. The ingredients were practically free, and there was no way...


When Depression Gets Worse on an Antidepressant

February 14, 2021 | Podcasts

Bupropion and restless legs syndrome: a randomized controlled trialWhen a patient complains that their mood got worse on an antidepressant, it doesn’t necessarily mean they are sensitive to medications. In this episode, we detail 6 other reasons why depression can...


Deprescribing Part 1

February 8, 2021 | Podcasts

An interview with Swapnil Gupta on when and how to come off psychiatric medications. Plus, tips on cross-tapering antidepressants, and the word of the day: Ephedra. Published On: 2/8/2021 Duration: 17 minutes, 1 second Transcript: Today, an interview with Swapnil Gupta on...


The Birth of Lamotrigine

January 25, 2021 | Podcasts

Richard Weisler tells the tale of science and serendipity that lead to his discovery of lamotrigine for bipolar depression 30 years ago. He shares a few dosing tips, and touches on how he works with patients and their families. Plus,...


Cognitive Enhancers: The Brain on Chess

January 11, 2021 | Podcasts

The Queen’s Gambit is Netflix’s critically acclaimed series about a chess prodigy who gets “a little help from her friends.” In this episode we find out what they got right, and wrong, about psychiatric meds and cognitive enhancement. Published On: 1/11/2020...


Rebuilding Life after Bipolar

January 4, 2021 | Podcasts

Brett Stevens has lived through the worst of bipolar and come out standing. Here’s what he did to get his life back. This is the first edition of The Pocket Psychiatrist, a monthly series you can share with your patients...


What We Learned in 2020

December 28, 2020 | Podcasts

A look at the top 10 practice-changing highlights from our 2020 journal. Tardive dyskinesia, inflammation, lumateperone, top first-line medications, trazodone in depression, Silexan for anxiety, excellent lithium responders, hormones and mood, and ramelteon’s generic debut. Published On: 12/28/2020 Duration: 26...



December 21, 2020 | Podcasts

Retractions are on the rise in medical research, and we get to the bottom of it with Ivan Oransky, cofounder of Published On: 12/21/2020 Duration: 25 minutes, 12 seconds Rough Transcript: Can you personalize antidepressant selection, use antipsychotics in dementia,...