When family-based therapy stalls in adolescents with anorexia, what comes next? A retrospective matched-cohort study suggests that low-dose aripiprazole may loosen cognitive rigidity enough to get treatment moving again — with doses averaging under 3 mg/day and a surprisingly favorable side-effect profile.

Do antipsychotics during pregnancy increase long-term neurodevelopmental risk? Large US and Nordic registry studies, along with prospective data, provide reassuring findings. After adjusting for maternal illness, prenatal exposure was not meaningfully associated with intellectual, language, or learning disorders—important context for shared decision-making.

The analysis ranks the efficacy of ketamine, esketamine, lithium, and aripiprazole in TRD.

Five strategies to reduce prolactin on antipsychotics tested in this meta-analysis

By initiating LAIs early in the course of a patient’s illness, we can significantly delay the time to first hospitalization in young adults. 

This large study gives us reassuring data about neurodevelopmental outcomes in children exposed to several second-generation antipsychotic medications during pregnancy.

Antipsychotics can be very effective for irritability in autism, but they are often unnecessary, and the side effects are truly problematic. Don’t be the prescriber who hears irritability in autism and immediate prescribes antipsychotics. There are usually multiple steps to try before using the FDA approved antipsychotic medications.

This study identifies a common clinical scenario where aripiprazole may trigger psychotic symptoms.

Dosing recommendations for aripiprazole vary widely in depression, from 2 mg to 15 mg, but this meta-analysis finds a sweet spot in the lower range.