Research findings favor augmentation over switching strategies in treatment-resistant depression. Aripiprazole augmentation showed superior efficacy and lower fall rates compared to other approaches in older adults.

It’s not just finding the antidepressant—dose, duration, and augmentation strategies matter.

Treating depression in older adults can be challenging, especially when first-line therapies fail. We review evidence-based strategies for treatment-resistant depression, from medication adjustments and augmentation to neuromodulation and lifestyle interventions.

With numerous treatment options available for bipolar depression and mania, clinicians often struggle to navigate between medication classes in balancing side effects, efficacy, and costs. Dr. Beyer shares his expertise in choosing first-, second-, third-, and fourth-line options based on their evidence in older adults.