SSRIs - Page 1 | CARLAT PUBLISHING

Research Update

Bupropion for Anxious Depression: Not as Activating as You Think

October 1, 2026

Reviewed by Jesse Koskey, MD. Dr. Koskey has no financial relationships with companies related to this material.

Clinicians often avoid this antidepressant in anxious patients, fearing it revs them up—new research finally tests whether that worry holds up.

Clinical Update

Pharmacological Treatments for Autism

August 1, 2026

Shiyu Chen, MD and Chris Aiken, MD

Chris Aiken, MD. Editor-in-Chief, The Carlat Psychiatry Report; Assistant Professor, NYU Langone Department of Psychiatry; practicing psychiatrist, Winston-Salem, NC. Shiyu Chen, MD. Chief resident, Family Health Centers at NYU Langone Psychiatry Residency Program, Department of Psychiatry, Brooklyn, NY.

The authors have no financial relationships with companies related to this material.

No drug targets autism's core symptoms, but medications from antipsychotics to leucovorin can address irritability, sleep, attention, and other co-occurring challenges.

Free Sample Table: Hyperbolic Taper for SSRIs

June 6, 2026

Chris Aiken, MD

If a patient is tapering off SSRIs completely — rather than switching to another antidepressant — a hyperbolic taper minimizes the risk of withdrawal.

Clinical Update

Benzodiazepine Use in Kids and Teens: When Is It Safe, When Is It Effective?

October 1, 2025

Anthony Charuvastra, MD and Tal Tetzeli

Anthony Charuvastra, MD. Assistant professor, Department of Child and Adolescent Psychiatry, NYU Langone, New York, NY.

Tal Tetzeli. Research assistant, Department of Child and Adolescent Psychiatry, NYU Langone, New York, NY.

Dr. Charuvastra and Ms. Tetzeli have no financial relationships with companies related to this material.

Are benzodiazepines ever appropriate for children? This evidence-based update explains why SSRIs remain first-line for pediatric anxiety, the rare instances when short-term BZD use makes sense, and the key risks clinicians must weigh—including dependence, interference with therapy, and drug diversion.

Research Update

Do SSRIs Trigger Mania in Kids?

October 1, 2025

Joshua Feder, MD

Joshua Feder, MD. Dr. Feder has no financial relationships with companies related to this material.

Do SSRIs unmask bipolar disorder in youth? A new Swedish cohort study addresses whether SSRIs trigger mania in children and adolescents with unipolar depression. Learn which risk factors warrant closer monitoring.

RESEARCH UPDATE

SSRI-Induced Sexual Dysfunction: Are Weekend Holidays Effective?

June 1, 2025

Dee Rapposelli

Dee Rapposelli. Ms. Rapposelli has no financial relationships with companies related to this material.

Two recent studies suggest that taking short, scheduled breaks from SSRIs may help reduce sexual side effects in both men and women.

Clinical Update

Unraveling Post-SSRI Sexual Dysfunction

September 26, 2024

Awais Aftab, MD.

Awais Aftab, MD. Psychiatrist in Cleveland, Ohio, and Clinical Assistant Professor of Psychiatry at Case Western Reserve University. Author of the online newsletter Psychiatry at the Margins.

Dr. Aftab has no financial relationships with companies related to this material.

Patient advocacy groups are adamant that it exists. European regulators have given it the stamp of approval. Here, we look at the evidence that sexual dysfunction can persist long after stopping an SSRI.

Expert Q&A

Looking Back on Prozac

September 3, 2024

Peter D. Kramer, MD

Peter D. Kramer, MD

Emeritus Professor of Psychiatry and Human Behavior, Brown University. Author of eight books, including the runaway bestseller Listening to Prozac (Viking Adult, 1993) and Death of the Great Man (Post Hill Press, 2023).

Dr. Kramer has no financial relationships with companies related to this material.

Dr. Kramer examines how certain antidepressants can alter personality traits, while also exploring the ethical concerns and long-term effects of these changes.

Research Update

DBT for Borderline Personality Disorder: Is Half the “Dose” Effective?

October 3, 2023

Kate J. Travis, MD

Kate Travis, MD. Dr. Travis has no financial relationships with companies related to this material.

Major depressive disorder, mood disorders, SSRIs, borderline personality disorder

Throwback Thursday: Neuroticism and SSRIs

September 7, 2023

Chris Aiken, MD and Kellie Newsome, PMHNP

"I think that anxiety is the fever of psychiatry, not a disease, it's not a diagnosis, it's not an illness. It's just a symptom, usually of other illnesses or condition." - Nassir Ghaemi