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Fact Sheet

Brexpiprazole (Rexulti) Fact Sheet for General Psychiatry

November 18, 2025

Talia Puzantian, PharmD, BCPP and Daniel Carlat, MD

Dr. Carlat and Dr. Puzantian have no financial relationships with companies related to this material.
Full Fact Sheet Editorial Information

Brexpiprazole is a partial dopamine agonist closely related to aripiprazole, with similar efficacy.

Expert Q&A

Pharmacotherapy for Dementia

March 1, 2025

Stephanie Collier, MD

Director of Education in the Division of Geriatric Psychiatry at McLean Hospital and an instructor in psychiatry at Harvard Medical School. Editor-in-Chief, The Carlat Geriatric Psychiatry Report.

Dr. Collier has no financial relationships with companies related to this material.

We have three newly approved meds for dementia. Brexpiprazole (Rexulti) for agitation, and donanemab (Kisunla) and lecanemab (Leqembi) for the core features of Alzheimer’s. Dr. Collier explains why none of these are first-line.

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