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Research Update

Bupropion for Anxious Depression: Not as Activating as You Think

October 1, 2026

Reviewed by Jesse Koskey, MD. Dr. Koskey has no financial relationships with companies related to this material.

Clinicians often avoid this antidepressant in anxious patients, fearing it revs them up—new research finally tests whether that worry holds up.

How to Start a Psych Medication VI

September 22, 2025

Chris Aiken, MD and Kellie Newsome, PMHNP

Lithium, pramipexole, bupropion, carbamazepine, valproate, and trazodone. Meds that require special skill to start:

Weight Changes and Antidepressants: What to Tell Patients

May 1, 2025

Dominic Le, MD

Dominic Le, MD. Dr. Le has no financial relationships with companies related to this material.

When patients ask about weight changes with antidepressants, providing guidance can be challenging. While bupropion is often considered weight-neutral and paroxetine an offender, how do other common antidepressants compare?

Psych Meds That Cause Weight Loss

May 1, 2025

Chris Aiken, MD

Chris Aiken, MD. Editor-in-Chief, The Carlat Psychiatry Report. Assistant Professor, NYU Langone Department of Psychiatry. Practicing psychiatrist, Winston-Salem, NC.

Dr. Aiken has no financial relationships with companies related to this material.

Some patients will only take a psych med that is weight neutral. We found nine that can cause weight loss.

Research Update

How Do We Help Depressed Smokers Quit?

October 1, 2024

Justin Morales, MD and Deepti Anbarasan, MD

Justin Morales, MD, and Deepti Anbarasan, MD. Drs. Morales and Anbarasan have no financial relationships with companies related to this material.

Tobacco smoking and major depression are highly comorbid, and depressed patients usually have a tougher time quitting than their non-depressed counterparts. In this research study, investigators compared the efficacy of anti-smoking medications in those with depression. The results may surprise you.

Research Update

Efficacy of Auvelity for Major Depression

April 1, 2024

Nina Chandler, DNP, APRN, PMHNP-BC

Nina Chandler, DNP, APRN, PMHNP-BC. Dr. Chandler has no financial relationships with companies related to this material.

A dextromethorphan-bupropion combo tablet shows promise in treating major depression. The FDA recognized its potential in 2019, so stay tuned for more updates on this novel treatment.

Uncontrolled Misuse

October 23, 2023

Chris Aiken, MD and Kellie Newsome, PMHNP

There are many reasons why patients misuse medications. Today, Joseph Pierre shakes us out of our 1990s understanding of addiction and explains a new trend, misuse of uncontrolled medications like Bupropion, Quetiapine and the Gabapentinoids.

Fact Sheet

Bupropion (Wellbutrin, others) for Children and Adolescents

September 22, 2023

Joshua Feder, MD, Elizabeth Tien, MD, and Talia Puzantian, PharmD, BCPP

Dr. Feder, Dr. Tien, and Dr. Puzantian have no financial relationships with companies related to this material.
Full Fact Sheet Editorial Information

Not a first-line antidepressant in kids, but may be useful when depression includes fatigue and poor concentration.

Clinical Update

Are Two Antidepressants Better Than One?

July 3, 2023

Michael Posternak, MD.

Michael Posternak, MD. Psychiatrist in private practice, Boston, MA.

Dr. Posternak has no financial relationships with companies related to this material.

New research calls to question the common practice of antidepressant combinations. Dr. Posternak makes sense of it.

Clinical Update

Treatment of Antipsychotic-Induced Weight Gain

September 1, 2022

Brian Miller, MD, PhD, MPH

Brian Miller, MD, PhD, MPH. Professor of Psychiatry at the Medical College of Georgia, Augusta, and President of the Georgia Psychiatric Physicians Association.

Dr. Miller, author of this educational activity, receives research support from Augusta University; the National Institute of Mental Health; the Brain and Behavior Research Foundation; and the Stanley Medical Research Institute. Relevant financial relationships listed for the author have been mitigated.

From lifestyle changes to liraglutide, Brian Miller details best practices for managing this insidious side effect.